ID R4T4B7_9PSEU Unreviewed; 2635 AA.
AC R4T4B7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Peptide synthetase, putative {ECO:0000313|EMBL:AGM05508.1};
GN ORFNames=AORI_2922 {ECO:0000313|EMBL:AGM05508.1};
OS Amycolatopsis keratiniphila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
OX NCBI_TaxID=129921 {ECO:0000313|EMBL:AGM05508.1, ECO:0000313|Proteomes:UP000013968};
RN [1] {ECO:0000313|EMBL:AGM05508.1, ECO:0000313|Proteomes:UP000013968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HCCB10007 {ECO:0000313|EMBL:AGM05508.1,
RC ECO:0000313|Proteomes:UP000013968};
RX PubMed=23627759; DOI=10.1186/1471-2164-14-289;
RA Tang B., Wang Q., Yang M., Xie F., Zhu Y., Zhuo Y., Wang S., Gao H.,
RA Ding X., Zhang L., Zhao G., Zheng H.;
RT "ContigScape: a Cytoscape plugin facilitating microbial genome gap
RT closing.";
RL BMC Genomics 14:289-289(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP003410; AGM05508.1; -; Genomic_DNA.
DR RefSeq; WP_016333275.1; NC_021252.1.
DR KEGG; aoi:AORI_2922; -.
DR PATRIC; fig|1156913.3.peg.2993; -.
DR HOGENOM; CLU_000022_44_2_11; -.
DR Proteomes; UP000013968; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000013968}.
FT DOMAIN 491..566
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1523..1599
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2542..2617
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2635 AA; 277633 MW; 6DC467EAB9D0E8D7 CRC64;
MRVHEAFEAQ AKRTPHRCAL VAGDERLSYA RLDEIANTVA HTLLRRGVAR GDLVGVCLRR
GRWLVPALLG ILKAGCAYVP LDPAAPPAHG ASVVADSGLS LVVADEPDAA ALADADVPVL
AVGDVVSAPT TAPAVPGSGT DLAYVIYTSG STGRPKGVQV EHRNVLALLA WAAATYTDDE
LRGVLGAASV CFDASVAEIF PPLVTGGSLV LAENLLALPG LAARDEVTFV QGVPSVLAVL
ARTPLPRSVR TVAIAGEALH RSLVDRLYAN EGVRRIVNCY GPTEATVNCS CHEVGRDEPD
DPPIGTALPG AAFSVRDADG RVLGDDEVGE LWVSGALVTR GYLGQPELTA EKFVVDSGGV
RHYRTGDLVR ARDGVHHFVG RADDQVKVRG FRIEPGQVQA ALLTHPAVGN AVVLAPADEH
GERRLVGFAE PAGAPVSEPE LLRWLRSRLP AHLVPSRIAV LDAIPLGTTG KADRTALAAW
VFDREDVEYV APGTETERLV AEAVAAAFGL PGIGAHDRFS ESGGHSLAAA RAVARLREET
GRVVTLAEFL SDGTVAAVAR RLADAPVAAP SLPLGENPGT FPLTGTQRDL WTLAQLGSTG
TATTVAWRLR LRGRVSVPAL RAAADGLVAR HEVLRGTIGD HDGEPVMVVG PPVRVPVDVH
DLRGLADADH RAGELAAAAA RHAFDLTGDT PLLRITLLRL ADDVADLVVV SDHIATDGAS
IGVLMAELAG APAPSFAQVG AVASRERALA RVPGERDRLA AYWSEELAGA NPPDALFDRA
AHGRRRFGGE RISTPLPESL GSAVRALAES TGVTPFAVYL SALGLLVGEL VRGRDVLLGM
AAAHRDRPEL EHTVGPLVDV LPVRLRLDAG TSFRDLLRAA MTTAARAIDH RGLPSGELAG
LWGGDRPAGV PLTPVSIAVQ PDGLPLSVHG PGTRLDLLGE LPTGGSHNPL TVFVNTHADG
TELIVEHDPS WLAPDRARWF SRSLLRFLHI AVSTPDTALS ELAVASDGEL AELTRWGTGP
ALPADDASGV PDAVWRAASR TPDAVAVSSE GGQLTYAELV GHADRIARVL AASGVTAGDT
VGVCLPRDEF LPAALLAVWR AGAGYLPLDT GQPVARLAQL ADEAGLRVVL TRGGAEPMAA
EVADAVPGLR VISADSADGA SFEPVLPDGD ALAYVLYTSG STGRPKGVEI SHANLHAFIR
SRGLLPGMTR DDAMLAVAPL AFDVSAEELW WPLTTGARCV VADRDTAVDG HELARRIAES
GVTVVDLTPT SLRMLLAAGW TGDPELRLLL GGEVLDPDLA ARARPLVGEL WNGYGPTETT
VSATAHRVTE HDRERVPIGS PTPGARLYVL DEAGRLAPPG AIGELWIGGT GVATGYRARP
ELTGSAFVTD PVRPGERCYR TGDLVRWRPE ATLEFLGRAD DQVKVRGNRF EPGEIESVLR
GLSDVDDAAV TVAADGVDAH VIGYLTPATV DAAAVERRLR RLLPAYMVPT SWCALDALPL
LPNGKLDRRA LPPSSVARPG TVAPLSEAEA SVARVWRDCL ELDGEIGPDS DFFALGGRSL
AATRVVGLLH ARLGRRITVR TLFDHPVLAD FTAQVGEEAD RPLVAREDPA APAPLSPAQR
MLWFAAKLDP GSAAYNSPTV LRILGALDEP RLFRAIRTLA ARHHVLRSRF TEIDGEPVAL
LGPVDAVPMS TVDVREPDLA AAVTAEIRRP FALDAAPPLR VVLFRLAPDH HVLALTCHHI
ATDATSQRLL LSEMDTWYRT EPGGPPPSVQ YAAHAARERE QDRAAGLDWW ERRLADLPAL
RLPADRPRPA VADRTADEVP LRLPADVTER VRALARTAGT TPFTVLLAAW QLLLARLAGV
RDLAVAVPHS GRRTAELAEM VGFFVDTVAV RADLGSDVRS GRDLVARTRD AVLDAFAHAD
VPFDEVVRRL APERDPASTP VCQVMMNVLD EQAAATLGDL AVTVLPQPVA TALYDLNLDL
AETGDGYTGR LVFRTGLFDR DTVERWARWY GSLVDRLTAD PGAALSTLDI LNDAERAALL
TWGTGKPSPA TRTVVTDVLA QQHGAMATSS PTGRLSYADL AAWSAQGARA LLAAGVATGE
VVGVCLPRDE YLPAGLLAVW RAGGAYLPLD PGQPADRIAA LAADAGIRVV AARGQALDAA
RAALPNLTIV DLDVPVTNTL PLREPGQDDL AYVLYTSGST GRPKGVAVTH RNLAALVHAF
REVTGVRPSD TWLAVAPLAF DTATGEIWTT LTAGAHCAIA DRDCAVDGHA LVRRLVSTGA
TRFNPTPTTL RMLVAAGLPD LPGLHVLSGG EALDVALARQ VAARVASLRN CYGPTETTIT
ATTHLVTVTD LAADRPIPIG GPLGGTLLTV VDPFGQTALP GAVGELSIGG AGVTPGYRDR
PERTAAAFGT DPLHGVRSYR TGDLVRWRAD GALEFHGRAD HQVKIRGNRV ELGEVEHVLR
TVDGVTGAVV VVRTGEGEPH LVGYLTPSTV DTDAVAAVLR DRLPDYAVPH RWVPLDVFPA
TATGKVDRAA LPAPAAAQPD SEPESAVEEL VAVIWAEALG RERVGALDDF FGLGGHSLAA
TKVVGRLGEA LGFPVPVRCL FDRPVLRDFA AELERIAMTA LADEGTIDVP AKSTA
//