ID R4TBM2_9PSEU Unreviewed; 338 AA.
AC R4TBM2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Cobalamin synthesis protein {ECO:0000313|EMBL:AGM07858.1};
GN Name=cobW {ECO:0000313|EMBL:AGM07858.1};
GN ORFNames=AORI_5275 {ECO:0000313|EMBL:AGM07858.1};
OS Amycolatopsis keratiniphila.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
OX NCBI_TaxID=129921 {ECO:0000313|EMBL:AGM07858.1, ECO:0000313|Proteomes:UP000013968};
RN [1] {ECO:0000313|EMBL:AGM07858.1, ECO:0000313|Proteomes:UP000013968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HCCB10007 {ECO:0000313|EMBL:AGM07858.1,
RC ECO:0000313|Proteomes:UP000013968};
RX PubMed=23627759; DOI=10.1186/1471-2164-14-289;
RA Tang B., Wang Q., Yang M., Xie F., Zhu Y., Zhuo Y., Wang S., Gao H.,
RA Ding X., Zhang L., Zhao G., Zheng H.;
RT "ContigScape: a Cytoscape plugin facilitating microbial genome gap
RT closing.";
RL BMC Genomics 14:289-289(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CP003410; AGM07858.1; -; Genomic_DNA.
DR RefSeq; WP_016335599.1; NC_021252.1.
DR AlphaFoldDB; R4TBM2; -.
DR KEGG; aoi:AORI_5275; -.
DR PATRIC; fig|1156913.3.peg.5371; -.
DR HOGENOM; CLU_017452_1_1_11; -.
DR Proteomes; UP000013968; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SMART; SM00833; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000013968}.
FT DOMAIN 226..317
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|SMART:SM00833"
SQ SEQUENCE 338 AA; 37030 MW; D3C74B98D9C73D44 CRC64;
MVDRRIPVIL VAGFLGSGKT TLLNHLLANR QGARIGVVVN DFGSIAVDAM AVSGQVDTMM
SFGNGCLCCA VDASGLDAML AKLSEAEAGI DVIVIEASGL AEPRDLIRLM IASENPVIAY
GGLVELVDAA EFESTRKRHP ELDEHLGFAD LVVLNKTDRA DEETLAKLRG TIDEIAPGTP
VIATSHGRID PTLFFDARPR ERVGQMSFDD LREEEHDHEH HFHTAYDSVA FTTERPLDPR
RLMDFLEQRP GGLYRIKGFL DFGPNGARSR FGLHTVGSFI QLERSAWPSG RPRRSELVLI
GSGIDTEAVT ARLEACVADD PEVVDERGML RVLRFIQD
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