ID R4VVP8_9EURY Unreviewed; 147 AA.
AC R4VVP8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Putative nickel-responsive regulator {ECO:0000256|HAMAP-Rule:MF_00476};
GN ORFNames=L593_06640 {ECO:0000313|EMBL:AGN01275.1};
OS Salinarchaeum sp. Harcht-Bsk1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Natronoarchaeaceae; Salinarchaeum.
OX NCBI_TaxID=1333523 {ECO:0000313|EMBL:AGN01275.1, ECO:0000313|Proteomes:UP000014072};
RN [1] {ECO:0000313|EMBL:AGN01275.1, ECO:0000313|Proteomes:UP000014072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Harcht-Bsk1 {ECO:0000313|EMBL:AGN01275.1};
RX PubMed=23868130;
RA Dominova I.N., Sorokin D.Y., Kublanov I.V., Patrushev M.V.,
RA Toshchakov S.V.;
RT "Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T,
RT Isolated from Hypersaline Lake Baskunchak, Russia.";
RL Genome Announc. 1:E00505-13(2013).
CC -!- FUNCTION: Transcriptional regulator. {ECO:0000256|ARBA:ARBA00002339,
CC ECO:0000256|HAMAP-Rule:MF_00476}.
CC -!- COFACTOR:
CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00476};
CC Note=Binds 1 nickel ion per subunit. {ECO:0000256|HAMAP-Rule:MF_00476};
CC -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC {ECO:0000256|ARBA:ARBA00008478, ECO:0000256|HAMAP-Rule:MF_00476}.
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DR EMBL; CP005962; AGN01275.1; -; Genomic_DNA.
DR RefSeq; WP_020446169.1; NC_021313.1.
DR AlphaFoldDB; R4VVP8; -.
DR STRING; 1333523.L593_06640; -.
DR GeneID; 16180836; -.
DR KEGG; sali:L593_06640; -.
DR PATRIC; fig|1333523.5.peg.1355; -.
DR eggNOG; arCOG01008; Archaea.
DR HOGENOM; CLU_113319_0_0_2; -.
DR OrthoDB; 9459at2157; -.
DR Proteomes; UP000014072; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR CDD; cd22231; RHH_NikR_HicB-like; 1.
DR Gene3D; 3.30.70.1150; ACT-like. Chain A, domain 2; 1.
DR Gene3D; 1.10.1220.10; Met repressor-like; 1.
DR HAMAP; MF_00476; NikR; 1.
DR InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR InterPro; IPR002145; CopG.
DR InterPro; IPR022988; Ni_resp_reg_NikR.
DR InterPro; IPR010985; Ribbon_hlx_hlx.
DR InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR PANTHER; PTHR34719; NICKEL-RESPONSIVE REGULATOR; 1.
DR PANTHER; PTHR34719:SF2; NICKEL-RESPONSIVE REGULATOR; 1.
DR Pfam; PF08753; NikR_C; 1.
DR Pfam; PF01402; RHH_1; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF47598; Ribbon-helix-helix; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00476};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00476};
KW Nickel {ECO:0000256|ARBA:ARBA00022596, ECO:0000256|HAMAP-Rule:MF_00476};
KW Reference proteome {ECO:0000313|Proteomes:UP000014072};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00476};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00476}.
FT DOMAIN 4..40
FT /note="Ribbon-helix-helix protein CopG"
FT /evidence="ECO:0000259|Pfam:PF01402"
FT DOMAIN 54..129
FT /note="Transcription factor NikR nickel binding C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08753"
FT BINDING 77
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT BINDING 88
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT BINDING 90
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT BINDING 96
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
SQ SEQUENCE 147 AA; 16722 MW; 04C83D7FEAB5B2C3 CRC64;
MAVVSVSMPD ELLDRLDEFS EEHGYTGRSE VVREASRNLL GEFEDASLED KELMGVVTVV
FDYETTNVEQ RMTELRHEHE HLVASNFHSH VAERYCMELF VLEGTLPEIS TFVGKIRATH
DTLSVDYSVH PIEEFSQTLE AAEEASD
//
