ID R4VXP0_9EURY Unreviewed; 345 AA.
AC R4VXP0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Aspartate-semialdehyde dehydrogenase {ECO:0000313|EMBL:AGN02025.1};
DE EC=1.2.1.11 {ECO:0000313|EMBL:AGN02025.1};
GN ORFNames=L593_10400 {ECO:0000313|EMBL:AGN02025.1};
OS Salinarchaeum sp. Harcht-Bsk1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Natronoarchaeaceae; Salinarchaeum.
OX NCBI_TaxID=1333523 {ECO:0000313|EMBL:AGN02025.1, ECO:0000313|Proteomes:UP000014072};
RN [1] {ECO:0000313|EMBL:AGN02025.1, ECO:0000313|Proteomes:UP000014072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Harcht-Bsk1 {ECO:0000313|EMBL:AGN02025.1};
RX PubMed=23868130;
RA Dominova I.N., Sorokin D.Y., Kublanov I.V., Patrushev M.V.,
RA Toshchakov S.V.;
RT "Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T,
RT Isolated from Hypersaline Lake Baskunchak, Russia.";
RL Genome Announc. 1:E00505-13(2013).
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DR EMBL; CP005962; AGN02025.1; -; Genomic_DNA.
DR RefSeq; WP_020446919.1; NC_021313.1.
DR AlphaFoldDB; R4VXP0; -.
DR STRING; 1333523.L593_10400; -.
DR GeneID; 16180181; -.
DR KEGG; sali:L593_10400; -.
DR PATRIC; fig|1333523.5.peg.2144; -.
DR eggNOG; arCOG00494; Archaea.
DR HOGENOM; CLU_049966_1_0_2; -.
DR OrthoDB; 38238at2157; -.
DR Proteomes; UP000014072; Chromosome.
DR GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom.
DR NCBIfam; TIGR00978; asd_EA; 1.
DR PANTHER; PTHR46718; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR46718:SF1; ASPARTATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF01118; Semialdhyde_dh; 1.
DR Pfam; PF02774; Semialdhyde_dhC; 1.
DR PIRSF; PIRSF000148; ASA_dh; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AGN02025.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014072}.
FT DOMAIN 4..131
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
FT ACT_SITE 150
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
FT ACT_SITE 243
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000148-1"
SQ SEQUENCE 345 AA; 36263 MW; FF2DBA8C359C2ACF CRC64;
MSVRVGVIGA TGAVGQRLIQ QLAPHDDFEI AALTASESSA GKPYSEAAKW RASGPIPDGV
GDVTVVETDP SAVGDDVDLL FSSLPSSVGE RVEPAFAEAG YVVSSNSSNG RLDDDVPLVI
PEVNADHVDL IEVQRDERGW DGALLKNPNC STITMVPPLA ALDDAFGLES VTVSTLQAVS
GAGYDGVTSM EIIDNVLPHI GGEETKMETE TCKLLGGFDG AELSWHDVEV SASCNRVPTL
DGHLENVWAE TAEDAGPAEA EQAFRDMPSV DLPSAPEQLI HVHEDPNRPQ PRLDRDAEGG
QAISVGPVQE TPDGILFDSL AHNTIRGAAG ASVLNGELLL ERGYL
//
