ID R4W1C9_9EURY Unreviewed; 398 AA.
AC R4W1C9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AGN02396.1};
GN ORFNames=L593_12275 {ECO:0000313|EMBL:AGN02396.1};
OS Salinarchaeum sp. Harcht-Bsk1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Natronoarchaeaceae; Salinarchaeum.
OX NCBI_TaxID=1333523 {ECO:0000313|EMBL:AGN02396.1, ECO:0000313|Proteomes:UP000014072};
RN [1] {ECO:0000313|EMBL:AGN02396.1, ECO:0000313|Proteomes:UP000014072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Harcht-Bsk1 {ECO:0000313|EMBL:AGN02396.1};
RX PubMed=23868130;
RA Dominova I.N., Sorokin D.Y., Kublanov I.V., Patrushev M.V.,
RA Toshchakov S.V.;
RT "Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T,
RT Isolated from Hypersaline Lake Baskunchak, Russia.";
RL Genome Announc. 1:E00505-13(2013).
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DR EMBL; CP005962; AGN02396.1; -; Genomic_DNA.
DR RefSeq; WP_020447290.1; NC_021313.1.
DR AlphaFoldDB; R4W1C9; -.
DR STRING; 1333523.L593_12275; -.
DR GeneID; 16179838; -.
DR KEGG; sali:L593_12275; -.
DR PATRIC; fig|1333523.5.peg.2525; -.
DR eggNOG; arCOG00249; Archaea.
DR HOGENOM; CLU_009834_2_0_2; -.
DR OrthoDB; 275224at2157; -.
DR Proteomes; UP000014072; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014072}.
FT DOMAIN 8..209
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 235..311
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 330..392
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT REGION 57..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 41923 MW; 3A371F6D9D4E7ED4 CRC64;
MTRPNATGVV GAGLMGRDIA GLLANGGFPV TLVDVDPDAL ALARDYHETE LVDALADAGF
DPDGARDTGD DEATGGARDT GDDEATDDSV DAGAGLLGHI EYDTDLAALG DCEFVVEAVP
ERLELKRDLL ADLETVLGDD AVIGTNTSSL TPGEIAADAA APERVVLFHF ANPALERDIV
EISGDDATDH ALSTATDVAE AIGRTPILLD AEYRANCLSR LSASIKCAGT WELLEAEAAA
IDRGAAAIGF DRGPIEFVDL IGVDVHLATV DNLGEAYGDR YAPPPAIRER MEAMVQAGDC
GKKSGRGFFE WDGDACRLPE VDEPHDVTPV VGALVNEAHR LVEDGVGDED TIDEVLRRGS
GGEIGPFDVE SMLGREFLRE ALEERYAETG AAVYDPIF
//
