ID R4W4F2_9EURY Unreviewed; 387 AA.
AC R4W4F2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Arsenical-resistance protein {ECO:0000313|EMBL:AGN01092.1};
GN ORFNames=L593_05715 {ECO:0000313|EMBL:AGN01092.1};
OS Salinarchaeum sp. Harcht-Bsk1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Natronoarchaeaceae; Salinarchaeum.
OX NCBI_TaxID=1333523 {ECO:0000313|EMBL:AGN01092.1, ECO:0000313|Proteomes:UP000014072};
RN [1] {ECO:0000313|EMBL:AGN01092.1, ECO:0000313|Proteomes:UP000014072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Harcht-Bsk1 {ECO:0000313|EMBL:AGN01092.1};
RX PubMed=23868130;
RA Dominova I.N., Sorokin D.Y., Kublanov I.V., Patrushev M.V.,
RA Toshchakov S.V.;
RT "Complete Genome Sequence of Salinarchaeum sp. Strain HArcht-Bsk1T,
RT Isolated from Hypersaline Lake Baskunchak, Russia.";
RL Genome Announc. 1:E00505-13(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59)
CC family. {ECO:0000256|ARBA:ARBA00010110}.
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DR EMBL; CP005962; AGN01092.1; -; Genomic_DNA.
DR RefSeq; WP_020445986.1; NC_021313.1.
DR AlphaFoldDB; R4W4F2; -.
DR STRING; 1333523.L593_05715; -.
DR GeneID; 16181472; -.
DR KEGG; sali:L593_05715; -.
DR PATRIC; fig|1333523.5.peg.1170; -.
DR eggNOG; arCOG02190; Archaea.
DR HOGENOM; CLU_022869_0_0_2; -.
DR OrthoDB; 326456at2157; -.
DR Proteomes; UP000014072; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0015103; F:inorganic anion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR004706; Arsenical-R_Acr3.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00832; acr3; 1.
DR PANTHER; PTHR43057:SF1; ARSENICAL-RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR43057; ARSENITE EFFLUX TRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
DR PIRSF; PIRSF005508; Acr3; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014072};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 387 AA; 41731 MW; AF7DF07A0FA3EE78 CRC64;
MSTTEAHEHG PNCDCESCGD PRSMDFLDKY LTLWIFGAMA LGVGLGHVAP SVTEPIQNLH
LVEIGLIAMM YPPLAKADYS QLRAVFSNWR VLGLSLVQNW LIGPTLMFGL AVFFFSGLVP
GLPARPEYFL GLVFIGMARC IAMVLVWNEL AEGSTEYVTG LVAFNSLFQI LTYGVYVWFF
ALVLPDQLGM TALADGITTF DVTPGQVFEA IVIFLGIPFA GGFLTRYVGT RTKGETWYDE
AFVPRIDPLT LVALLFTVVV MFATQGDAIV ASPGDVLLIA VPLTIYFVVM FLVSFRMGRS
IGADYSTTTA IGFTAASNNF ELAIAVAVAV FGVGSGVAFA TVVGPLIEVP VLLALVHVAL
YFQRRYDWGG FDAGRLDGAT AESAADD
//
