ID   R4WNI6_9BURK            Unreviewed;       704 AA.
AC   R4WNI6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   RecName: Full=Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein {ECO:0000259|Pfam:PF02602};
GN   ORFNames=BRPE64_ACDS06860 {ECO:0000313|EMBL:BAN22440.1};
OS   Caballeronia insecticola.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Caballeronia.
OX   NCBI_TaxID=758793 {ECO:0000313|EMBL:BAN22440.1, ECO:0000313|Proteomes:UP000013966};
RN   [1] {ECO:0000313|Proteomes:UP000013966}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23833137; DOI=10.1128/genomeA.00441-13;
RA   Shibata T.F., Maeda T., Nikoh N., Yamaguchi K., Oshima K., Hattori M.,
RA   Nishiyama T., Hasebe M., Fukatsu T., Kikuchi Y., Shigenobu S.;
RT   "Complete Genome Sequence of Burkholderia sp. Strain RPE64, Bacterial
RT   Symbiont of the Bean Bug Riptortus pedestris.";
RL   Genome Announc. 1:340-344(2013).
RN   [2] {ECO:0000313|EMBL:BAN22440.1, ECO:0000313|Proteomes:UP000013966}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RPE64 {ECO:0000313|EMBL:BAN22440.1};
RX   PubMed=29863457; DOI=10.1099/ijsem.0.002848;
RA   Takeshita K., Tamaki H., Ohbayashi T., Meng X.-Y., Sone T., Mitani Y.,
RA   Peeters C., Kikuchi Y., Vandamme P.;
RT   "Burkholderia insecticola sp. nov., a gut symbiotic bacterium of the bean
RT   bug Riptortus pedestris.";
RL   Int. J. Syst. Evol. Microbiol. 68:2370-2374(2018).
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DR   EMBL; AP013058; BAN22440.1; -; Genomic_DNA.
DR   RefSeq; WP_016344600.1; NC_021287.1.
DR   AlphaFoldDB; R4WNI6; -.
DR   STRING; 758793.BRPE64_ACDS06860; -.
DR   KEGG; buo:BRPE64_ACDS06860; -.
DR   PATRIC; fig|758793.3.peg.685; -.
DR   HOGENOM; CLU_015149_0_0_4; -.
DR   OrthoDB; 9787650at2; -.
DR   Proteomes; UP000013966; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR   GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR007470; HemX.
DR   PANTHER; PTHR38043; PROTEIN HEMX; 1.
DR   PANTHER; PTHR38043:SF1; PROTEIN HEMX; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF04375; HemX; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          20..264
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   REGION          281..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          408..463
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        327..345
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   704 AA;  74256 MW;  17A9F9E9DAAE3EA8 CRC64;
     MASERRATIV ITRPAGQSSA LLALLASAGF DTLEFPLIDI APVADDAPLR AALDELFLPP
     DAPARYALVV FVSPNAIDHA FSRLGAPWPA DLPVAAVGPG SVAALARQGV HAPSHRVISP
     STESADPRFD SEALFSAIEA HFGAQGLDGK RVLIVRGDGG REWLAERLTQ AGARVEKAAA
     YRRVLPEPSM QKWERIHALL ADAPGGRHAW LLTSSEGVRN LDELAHEHLT ADEIVLLKRT
     PLVCPHPRIA EAARGAGFDR ITVSGAGDER IAQSLEAAFP SDPAGASAQA HAASASNADA
     HASAAPSPSA PTDANPAIAP APQPAHHTAQ SRMTDSNDSK KASPQPNVTP PLPPNTPFTP
     FEQQKRSGNV GIVLLWLVIV VLAVAAGAGA FVLNRKFDRA DTQMSQRLAQ ADEQSADLRA
     KADQAASATT ALSTQIIQLQ GKLADAETHS QALQQQYQDL AANRDDWTVA EVEQILSSAS
     QQLQLTGNVQ LALFALQSAD TRLAATTGPQ VVAIRKAIAL DIDKLKATPT TDLSGLAIKL
     DTAIDQIDQL PLAGEAPIAP AHAQAAAPAN SASIAAATGE PRWKVLWRQI TSGIGQQLSS
     LVSVRRIDNA DAMLTSPDQG YFVRENVKLR LLSARLSLLS RSEPTLKSDL HAADAALARY
     FDPASKKVQA VRDLVKQVDQ ASFAVAVPNL NGSLAVVHQF KRGG
//