ID   R4Z0G3_9ACTN            Unreviewed;      1260 AA.
AC   R4Z0G3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN   ORFNames=BN381_390021 {ECO:0000313|EMBL:CCM64384.1};
OS   Candidatus Microthrix parvicella RN1.
OC   Bacteria; Actinomycetota; Acidimicrobiia; Acidimicrobiales;
OC   Microthrixaceae; Microthrix.
OX   NCBI_TaxID=1229780 {ECO:0000313|EMBL:CCM64384.1, ECO:0000313|Proteomes:UP000018291};
RN   [1] {ECO:0000313|EMBL:CCM64384.1, ECO:0000313|Proteomes:UP000018291}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RN1 {ECO:0000313|EMBL:CCM64384.1,
RC   ECO:0000313|Proteomes:UP000018291};
RX   PubMed=23446830; DOI=10.1038/ismej.2013.6;
RA   Jon McIlroy S., Kristiansen R., Albertsen M., Michael Karst S.,
RA   Rossetti S., Lund Nielsen J., Tandoi V., James Seviour R., Nielsen P.H.;
RT   "Metabolic model for the filamentous 'Candidatus Microthrix parvicella'
RT   based on genomic and metagenomic analyses.";
RL   ISME J. 7:1161-1172(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCM64384.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CANL01000033; CCM64384.1; -; Genomic_DNA.
DR   AlphaFoldDB; R4Z0G3; -.
DR   STRING; 1229780.BN381_390021; -.
DR   eggNOG; COG0457; Bacteria.
DR   HOGENOM; CLU_006232_0_0_11; -.
DR   OrthoDB; 135224at2; -.
DR   Proteomes; UP000018291; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR024983; CHAT_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF12770; CHAT; 1.
DR   Pfam; PF13424; TPR_12; 3.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018291};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          113..359
FT                   /note="CHAT"
FT                   /evidence="ECO:0000259|Pfam:PF12770"
FT   REPEAT          974..1007
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1014..1047
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1054..1087
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          1134..1167
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1260 AA;  138086 MW;  20A2C8798C6E299A CRC64;
     MADRLIVDLF GDGRVGVSRQ LHGEVAPTPG PDPVELVVPL SEKDLGELAW YLERYLVAPF
     GVYEDRGPEI ADRLVGWGEA LFGSVFGGGG ARDAYRSVRD RDRGVGLEID IRSDDPGLLG
     LPWELMVDPE RSRRLVTTAE SFNRMLLTAN LEPMAQVAGE GLRVLMVIAR PAGLADVDYG
     MIARPLLERL EAVRGRVTLE VLRPPTLEQL EQRLGEAADA GVPFHVVHFD GHGALGEAPG
     GGSPSMYDGA EGQLLFEDSG GAGSLVSATQ FAQVVRAGGV PVVVLNACQS GALGEVIESA
     VATRVLKEGA VSSVVAMSYS VYAVAAAEFM AAFYDGLFAG DPVGVAVTKG RRRLERRPGR
     PSPKGDMALA DWVVPVHYVR GDVSFPHLKA APAAAGRHDF ELDAILDKID NGPEGADVLA
     ARDGVFVGRD DSFFELEAVC AHERVGIIVG PAGTGKTEVA KAFGRWRRDT GALDHPDGVF
     FMSFEPGVAS FGLDGVINTI GTRLFPTQFH QLDREHREEV VVSVLRDHRF LVVWDNFESV
     HSMPDPHQAT ATLNDNERTR LKKFVDQIGA PDGKTTLLIT SRSPEPWLET TPRRLGLGGL
     GERAADAYTD HLLNRLPNAQ ARRKQRAFGE LKQWLHGHPL SMRLILPQLE VTDPANLLDA
     LKGNSELPAG FEADQGRTES LGASIHYSLV QLDDTTRQLL PAVALFESVV DAEVLRVFSA
     SEQVPERFAG IDTGQWIQAL DAAAATGLLT PLGANTYSIH PALPAYLHAQ WKLDATDQFE
     TEHNTATNAL LGAHAAFGTW LHTEIETGRA GLAFALIDWQ RRTMTKLIRH ALNTSQWDAC
     QNVLQPLDDY FDVRGLDEEA RAVVDLVRTA TEKPAGQSPV LDSEDGKLWL FAVGSEANRQ
     LRRQQLDAAY QTYDDLRVAL ENSPKSSTQQ RYLANQYHQL GIVAQKRGDL DQADGWYRKS
     LTTFEELDNR PGMATSYHQL GNVAQDRGDL DQADDWYRKS LTIREELGNR PGMAESYHQL
     GIVAQKRGDL DEADDWYRKS LTILEELGDR PGMATSYHQL GNVAQERGDL DQADDWYRKS
     LTIKEKLGNR PGMASSYHQL GIVAQDRGAL DQADDWYRKS LTIFEELGNR PGMARSYHQL
     GIVAYLRGDL DQADGWYRKS LAIKEELGSI GQGVTLALRG LLAEEQDRIN EAFGYAIRAV
     ALFEEFPHRS SGSAPAQLAR LTSQHGDTAL RDAWTATTGN QIPADVFNWI AEQDKGATDE
//