ID R5ALU6_9BACT Unreviewed; 554 AA.
AC R5ALU6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0000259|Pfam:PF00501};
GN ORFNames=BN456_00568 {ECO:0000313|EMBL:CCX44310.1};
OS Prevotella sp. CAG:1031.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262917 {ECO:0000313|EMBL:CCX44310.1, ECO:0000313|Proteomes:UP000018183};
RN [1] {ECO:0000313|EMBL:CCX44310.1, ECO:0000313|Proteomes:UP000018183}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:1031 {ECO:0000313|Proteomes:UP000018183};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX44310.1}.
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DR EMBL; CAWK010000098; CCX44310.1; -; Genomic_DNA.
DR AlphaFoldDB; R5ALU6; -.
DR STRING; 1262917.BN456_00568; -.
DR Proteomes; UP000018183; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF83; ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018183}.
FT DOMAIN 12..413
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 554 AA; 62029 MW; E2A9719FC65DF40C CRC64;
MDNENLLQLF QASFRENWDL PALSQYGRGT TMTYADLSRR IAQAHLMFRL FGVKRGDKIA
VMGKNTVSWV VSYMATLTYG AIVVPVLAEF NPEDAMHIIN HSGSVLLFVS GSVWEHMNFD
RMPGLKAALS LDDRSLLGEH PSNRGRARKA IEALPAAFAK VYPEGFRREN VKYPLIDPQT
VAEINYTSGT TGFSKGVMLT LDNLAGNTYY GVRSRLHFSG SRCLAFLPLA HAYGAAFDML
TPLGAGSHVT LLDKMPTPIL LVKAFSEVRP NLILCVPLIL EKIYKKQIAP MLERKSIKRM
MAVPLMDRIV YNKIRAKLVK AFGGEFSQVI VGGAPLNAEV EQFLHKINFP FTVGYGMTEC
GPLISYTYWR EFICGSSGRT LPGIMHSRID SSDPVNVPGE ICVKGQNVMK GYYKNPEATQ
AVLDPDGWLH TGDMGTRTPD GTLFIKGRYK TMILTATGQN IYPEEIEAKL NNMQYVAESL
VVERGRSLVA LVYPDYEVVD RDGITTEQLP AVMEAIRKEL NKKVAPYERI DKIQLRPTEF
EKTPKRSIKR FLYN
//
