ID   R5B710_9CLOT            Unreviewed;       399 AA.
AC   R5B710;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Transcriptional regulator/sugar kinase {ECO:0000313|EMBL:CCX51038.1};
GN   ORFNames=BN545_00471 {ECO:0000313|EMBL:CCX51038.1};
OS   Clostridium sp. CAG:226.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262781 {ECO:0000313|EMBL:CCX51038.1, ECO:0000313|Proteomes:UP000018047};
RN   [1] {ECO:0000313|EMBL:CCX51038.1, ECO:0000313|Proteomes:UP000018047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:226 {ECO:0000313|Proteomes:UP000018047};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor of xylose-utilizing enzymes.
CC       {ECO:0000256|ARBA:ARBA00002486}.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family.
CC       {ECO:0000256|ARBA:ARBA00006479}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCX51038.1}.
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DR   EMBL; CAWN010000231; CCX51038.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5B710; -.
DR   Proteomes; UP000018047; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR   PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR   Pfam; PF13412; HTH_24; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:CCX51038.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018047};
KW   Transferase {ECO:0000313|EMBL:CCX51038.1}.
SQ   SEQUENCE   399 AA;  42929 MW;  887D28A1B3F00E84 CRC64;
     MYQTSPKSQA DLKFHNLKLV FDLVKREGPT SRASLAKRTG LSPTSMTRIV NVLKRIGLIS
     EHSVAQAGVA GRPSTLLEIC ADAAYCLCVD AMPNVSKVTL VDMATKQAVY RELVTVSGTS
     FETVADELNA MLGEMCRDAG ITRDRIACCG MSISGHVLRN GYIAASSQMQ WADIDGVGIL
     ERALDMPAIV ENDCKAALLG EQYLLSCAGE STANMAYVKF GWAGVGSAAM VDGMLLRGSR
     NAAGEIGHFN SQLEGLSGDK CEFKGCFEHT ISESAVIEHA RSINQACASL AGVNEAIANG
     DERIIKLMND ICEYIAIAVS DISCAYNSDR IILSGNIITN LADCYQNVLR YVERRLTRSV
     QPNLQVCLSK MGTNASLYGM SCLAVEETIK RLLSNDTGF
//