ID R5BAJ3_9BACT Unreviewed; 466 AA.
AC R5BAJ3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BN689_00608 {ECO:0000313|EMBL:CCX52570.1};
OS Alistipes sp. CAG:514.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC Alistipes.
OX NCBI_TaxID=1262696 {ECO:0000313|EMBL:CCX52570.1, ECO:0000313|Proteomes:UP000018254};
RN [1] {ECO:0000313|EMBL:CCX52570.1, ECO:0000313|Proteomes:UP000018254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:514 {ECO:0000313|Proteomes:UP000018254};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX52570.1}.
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DR EMBL; CAWO010000112; CCX52570.1; -; Genomic_DNA.
DR AlphaFoldDB; R5BAJ3; -.
DR STRING; 1262696.BN689_00608; -.
DR Proteomes; UP000018254; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046138; DUF6140.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF03796; DnaB_C; 1.
DR Pfam; PF19637; DUF6140; 1.
DR Pfam; PF07669; Eco57I; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CCX52570.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018254};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 107..207
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT DOMAIN 285..386
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|Pfam:PF03796"
SQ SEQUENCE 466 AA; 52386 MW; 48B5B2D8BB65D284 CRC64;
MGRLAAYSGN KDVSILDPGC GLAILSCALI EHIVQEIVPE HISLTLYETD KKVVPLTEDV
LSYLKTWCGD RKVKLDYQLN ESDFVLEKCE CLDGTDTIFG DLSGTEKFDY IISNPPYFKL
AKDDIHTRSC ASIVDGQTNI YALFMAICAK LVAEDGQMIF ITPRSFASGR YFQSFRDFLF
QHVSIDLIHL FNTRKDTFAK DEVLQELVII RMVPAGNGKL ITVSYSQGIS DLDHPYQKKY
AASEIVDVSS EEKVVYLPVD GRDEAILSLF RSWDGNMEKP EPFRTNGPRE EEMDCVTKSL
KKAAEELKVP IIVLSQLQRG PDRPQMDDIS DSKDLKELAD VIILMHNGIG WDKIDGQIIG
EFIIAKNTRG NIGTVELTCD LKQGKFYEEI ISDGVTMKAF RITPKRIRRS NGQVLTPEMS
VVVSTNLSNP FNNGAKEVAE AYMRIYGFDY KRSCCCKTDF DCVLLG
//