ID R5BHD5_9CLOT Unreviewed; 1098 AA.
AC R5BHD5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN545_00314 {ECO:0000313|EMBL:CCX50861.1};
OS Clostridium sp. CAG:226.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262781 {ECO:0000313|EMBL:CCX50861.1, ECO:0000313|Proteomes:UP000018047};
RN [1] {ECO:0000313|EMBL:CCX50861.1, ECO:0000313|Proteomes:UP000018047}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:226 {ECO:0000313|Proteomes:UP000018047};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX50861.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAWN010000209; CCX50861.1; -; Genomic_DNA.
DR AlphaFoldDB; R5BHD5; -.
DR Proteomes; UP000018047; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR049035; ADDB_N.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR Pfam; PF21445; ADDB_N; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000313|EMBL:CCX50861.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018047}.
FT DOMAIN 271..561
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 1098 AA; 120277 MW; F43F8B1FD5700004 CRC64;
MRMGRVSILT GRSGSGKSRY LRSIAVELIK KGERVLYIVP EQFTFETERA LAETMGCGLW
DADVFSFTSL ARRVLNEFGE RRTLMSEQGR LMVIRKCADE LAPKLISFGR VYHRGGFTGE
CARFFIEAKR AGIEADALMD AANEKGTDTP LGAKLHDLAL LYGASEAYMA RTSLDAEESL
RLLSELLPKS ELGSRHVIID GFDMISRRLY GAIAALIDAA PHVTVALRID LSPECRDKAV
FSADRRILNK ILSICEERGI TPDFITPDDE QPRHASAALR HLEREGFAFP YNNFDGEANG
AIELFAATDV KAEVTAAAEK AQRLIDEGYR YRDIAIIASD TDKYLEPMMR ALRERHIPFF
TDAKRKLASY AASEATLFAL RAAGGSYLRE DMLALVKTGL CGVNAEQAEI FENYALARGI
RGSAFKSPFG EGAPAAAEEA RGIVMGPLEK LSEALKDAPT AAEKVRALYQ YTVDISLREQ
LTAEAEQLKA QGRLERADET AQVYNLLITV MEQMHAILGD AKISNRKFTS VYKEGIDAYE
VGVIPSAADQ LLLGSLGRSK ARSIRALIIL GAANGHFPAV YGDDGMIDDE ERASLAQMGL
GEMPSTAQLN DKEFGDAYGA VTKPTDKLWL SYTMGSGSDT ATPCELMDRI ADMFGDVSIK
TDIEEESAST APSAYSALIK HLRTGVENGH IDARAGELYA ALHKDSEYAR KLASLSSALF
PSVSAEPLGE DAAHRLYGAR LSGGITSIEK FNGCPFKHFA SVGLKLTPRK EYRERKADEG
LFCHEAMSLL TKELIAMGKG DGSITNDQLE TLLDSVLPKL IAQHNNGVLM DTARSRAAAA
RLIRRVKATA YAVVEQLRRG EFSISGTETE FGIGKRYPEL ILELPGGGRY ILSGRIDRID
SYTSDSGEKF VRVIDYKSES GSAFDCADIA DGKRLQLPLY IAAIEAAGAA ERAAGMYYLP
VHEGIIKPSG KEDDFATRIL KEFRLRGACL NDAKLIELGG GEDVQPTARS GWRLSEEQLK
GTVSFAVDKA RQTACKIAKG HAEAYPLMSK ENKTECEWCD YNSVCGFDAT LPCCKYRRAS
IIKKDDFLEE VSHAQLDR
//
