ID   R5BKT2_9BACT            Unreviewed;       805 AA.
AC   R5BKT2;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=BN689_01847 {ECO:0000313|EMBL:CCX52071.1};
OS   Alistipes sp. CAG:514.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC   Alistipes.
OX   NCBI_TaxID=1262696 {ECO:0000313|EMBL:CCX52071.1, ECO:0000313|Proteomes:UP000018254};
RN   [1] {ECO:0000313|EMBL:CCX52071.1, ECO:0000313|Proteomes:UP000018254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:514 {ECO:0000313|Proteomes:UP000018254};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCX52071.1}.
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DR   EMBL; CAWO010000075; CCX52071.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5BKT2; -.
DR   STRING; 1262696.BN689_01847; -.
DR   Proteomes; UP000018254; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07205; Pat_PNPLA6_PNPLA7_NTE1_like; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR043864; Omp85-like_dom.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF82; PATATIN-LIKE PROTEIN, PLPD; 1.
DR   Pfam; PF19143; Omp85_2; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018254};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..805
FT                   /note="PNPLA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004385599"
FT   DOMAIN          63..291
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   805 AA;  89321 MW;  20D80BE91CE20346 CRC64;
     MRTRTFRFLS IMAVAAAMTL SLHAQSQHSL LDENRERRDL RVEVIRHKLD SIRRVCHRPT
     VALVLSGGGA KGAAHVGVIR YLESIGMPVD IVMGTSMGGL VGGIYALGYN AKQLDSIIRD
     IDWDMALSDK VPRDYLSYSA IKYKEKYVLS FPFFYDKKDY QQMVESGQQY ARRADDIHFG
     AGGGDATNMV KDNLLGSLPS GMVYGQNVNN IFSSLSVGYQ DYTDFYDLPI PFLCVATDLV
     TGTAKVWTEG KLNTALRSTM SIPGLFAPVK IDGMVLVDGG MRNNYPTDLA KKAGADIVIG
     VNLSDGYKNY NQINNLADII NTGIDMLGRS SFESNIAIPD VNIKPDLHEY NMLSFDEASI
     DTIINRGYKA ALEVASKLDS IKAVVGPDVT RLANDPADDI RVRKVLVSGV EISGVDDKES
     LYLMNKIKVG AGSRMGNEEI EDAVATIFGT NSFDYVNYEL LGDQEPYKLM FNCQRGPVCQ
     LGLGGRFDSE EIVSVLINLG WGVHKIQGSS LDFTGKVGTN PYANLTYSHV STNGMTFNAM
     AGVRYTDRNM FSIGDNRFRI NFLDFRQEIY LSNIKWSKFF LKIGLRNDWY NVSSLMAEQA
     FGDYDVNQLS NDYVTFFLHG RKDSFDNAYI PTRGQSVGIS YDWVFGGGPN KFNNFHAIHF
     DAKKVVGDDR FAFIPSVNIR YLIGDEVPVP FTNTIGGSVA GRYLDQQIPF IGINNAAAMQ
     KIVGVARSDF RFKLFKNNYL TAMANYALTC NEISDFKDVS AKVSGYFGGG VQYTYNSIIG
     PVGLNVHWSE YTHNLGLYFS LGFDF
//