ID R5CGU0_9BACT Unreviewed; 486 AA.
AC R5CGU0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Serine protease HtrA {ECO:0000313|EMBL:CCX63992.1};
GN ORFNames=BN458_01226 {ECO:0000313|EMBL:CCX63992.1};
OS Prevotella sp. CAG:1058.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262918 {ECO:0000313|EMBL:CCX63992.1, ECO:0000313|Proteomes:UP000018314};
RN [1] {ECO:0000313|EMBL:CCX63992.1, ECO:0000313|Proteomes:UP000018314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:1058 {ECO:0000313|Proteomes:UP000018314};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX63992.1}.
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DR EMBL; CAWU010000022; CCX63992.1; -; Genomic_DNA.
DR AlphaFoldDB; R5CGU0; -.
DR STRING; 1262918.BN458_01226; -.
DR Proteomes; UP000018314; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011782; Pept_S1C_Do.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR NCBIfam; TIGR02037; degP_htrA_DO; 1.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF129; SERINE PROTEASE HTRA2, MITOCHONDRIAL; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:CCX63992.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018314};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 273..367
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 86..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 121
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
FT ACT_SITE 151
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
FT ACT_SITE 226
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
SQ SEQUENCE 486 AA; 52283 MW; D34C427E7BB656E0 CRC64;
MKKLSNYFVY AICIIAVAFS AGAFIKVNAN TNSMPAAQPV DLTYAAEKAL PAVVHIKYLQ
NSKVQTVEME ADPFDFFDPF GFFGNPGNGG KQKRRIQTPK REGSGSGVII SEDGYIVTNN
HVVEGADELT VTLDDNREFS ARIIGTDKTT DLALIKIDGK NLPTLSIGDS NDLKVGEWVL
AVGNPFNLKS TVTAGIVSAK ARTIGVSPSS VESFIQTDAA INAGNSGGAL VNTRGELVGI
NAMLVSQTGS YAGYGFAIPT TIMNKVVADL KQYGTVQRAM IGISGTDVNN YVDKMKEENK
EIDLGTMQGI YISEVEDNGA ASEAGLEKGD VITAIDGKKI TKMAELQEYL TNKRPGDKVT
ITYLRDKKSK TATLTLKNQQ GNTSIVKHAD LDVLGGNFRE INDNERKELN ISNGLVVMKV
NNGVLKDAGI NKGFIIQKVN DEPMKTIADL QKAVKDASTS KDPVLYIQGI YPTGKKAYFA
VPLQND
//
