ID R5CKE9_9FIRM Unreviewed; 609 AA.
AC R5CKE9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Oligoendopeptidase F {ECO:0000256|RuleBase:RU368091};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU368091};
GN ORFNames=BN785_01769 {ECO:0000313|EMBL:CCX65247.1};
OS Firmicutes bacterium CAG:791.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1262993 {ECO:0000313|EMBL:CCX65247.1, ECO:0000313|Proteomes:UP000018038};
RN [1] {ECO:0000313|EMBL:CCX65247.1, ECO:0000313|Proteomes:UP000018038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:791 {ECO:0000313|Proteomes:UP000018038};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Has oligopeptidase activity and degrades a variety of small
CC bioactive peptides. {ECO:0000256|RuleBase:RU368091}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU368091};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU368091};
CC -!- SIMILARITY: Belongs to the peptidase M3B family.
CC {ECO:0000256|RuleBase:RU368091}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX65247.1}.
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DR EMBL; CAWT010000128; CCX65247.1; -; Genomic_DNA.
DR AlphaFoldDB; R5CKE9; -.
DR STRING; 1262993.BN785_01769; -.
DR Proteomes; UP000018038; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09608; M3B_PepF; 1.
DR Gene3D; 1.10.1370.20; Oligoendopeptidase f, C-terminal domain; 1.
DR Gene3D; 1.20.140.70; Oligopeptidase f, N-terminal domain; 1.
DR Gene3D; 1.10.287.830; putative peptidase helix hairpin domain like; 1.
DR InterPro; IPR013647; OligopepF_N_dom.
DR InterPro; IPR042088; OligoPept_F_C.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR InterPro; IPR004438; Peptidase_M3B.
DR NCBIfam; TIGR00181; pepF; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR Pfam; PF08439; Peptidase_M3_N; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU368091};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU368091};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU368091};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU368091};
KW Reference proteome {ECO:0000313|Proteomes:UP000018038};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU368091}.
FT DOMAIN 111..179
FT /note="Oligopeptidase F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08439"
FT DOMAIN 200..581
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
FT COILED 577..604
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 609 AA; 69169 MW; 960AE5320526DB58 CRC64;
MEQERSQMNP KDQWDLSTLY ENDEAFEQDL ARMDADTDAA AAFEGKLRDA ETIAKFYQAM
TALQRRMNNL LTYAMLRQSE DTRAPKAQEL MAKGMNKAVL AESRCSFAEP EILALSEEKL
KEIADAKELL PYRFLLQELL DEKPHVLSAE AEQLLAGFSE VLEAPKTIAD SLMDADLSFD
SVKDREGNER ELSQANFILL EQSEDRTLRE NAFRSFYKGY ASHGNTLAAT YSGIVKSFAA
QARARHYESS RAMALAGEHI PASVYDGLVE SVRRHMPSMH RYVQLRKKLL GLDELHYYDV
YVPLTQGLSA QDSWSYEEAK SLVLEGLSPL GREYTDQVRK AFDDRWIDVY PNAGKRGGAF
SSGTYDSNPF ILMSYTGDYE SVSTIAHEMG HSMHTWYSKN HQPSYYADYT LFVAEVASTV
NENLLVEDLL KKTSDPTQRL FLLNQYLEGF KATVYRQTMF AEFERDAHAM AERGEALTPQ
ALNNLYRKLI EDYFGPELVL DEEVACEWSR IPHFYRPFYV YKYATSYAAA VALSEKILKE
GDQAVKPYLE FLSMGGSTYP LEELAHAGVD MTTTEPIDAA LEKFDRILDE AEQCAEELKA
AAAETPRQR
//