ID R5D1W2_9FIRM Unreviewed; 1154 AA.
AC R5D1W2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN457_01838 {ECO:0000313|EMBL:CCX74205.1};
OS Dorea sp. CAG:105.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX NCBI_TaxID=1262872 {ECO:0000313|EMBL:CCX74205.1, ECO:0000313|Proteomes:UP000017921};
RN [1] {ECO:0000313|EMBL:CCX74205.1, ECO:0000313|Proteomes:UP000017921}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:105 {ECO:0000313|Proteomes:UP000017921};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX74205.1}.
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DR EMBL; CAWY010000047; CCX74205.1; -; Genomic_DNA.
DR AlphaFoldDB; R5D1W2; -.
DR STRING; 1262872.BN457_01838; -.
DR Proteomes; UP000017921; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR049035; ADDB_N.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR Pfam; PF21445; ADDB_N; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017921}.
FT DOMAIN 281..567
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1120..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 134676 MW; 3930EC02000B8F6F CRC64;
MPLKFVMGPS GSGKTYQLYK NVIAESKAHP EENFIVLVPE QFTMQTQKDL VTMHDRHAIM
NIDVLSFVRL AYRIFEETGA GTLPVLDDEG KNLILRKIAG NHENELQMLR GNIRKLGYIS
EVKSVLSEFA QYDIGEEEID RVMENAGRES RLYYKLADMK VLYRGFQDYL KERYISKEEL
LDVLSRVVCK SEILKNSTIV LDGFTGFTPV QNRLLGELMK HCRKVMITVT IDPEEDPYRY
EHPYQLFALS KHMVTSMIQL AKENQIEIEE PMDLFDKIPY RFRDNPALAF LERNLFRYRK
ETYEGEQDAV KIHVAREPGE EALAAAQQVR AYMRENGYRC REIAVIVSDM EMYAEALEQA
FALYEIPVFM DHKRSILLNS FVEYIRSLLG MAEQNFTYES VFRFLRTNLA GFTHDEVDEL
ENYVIGMGIK GYKRWQEKWI RRLKDMKEED LERLNHYRTR FVEKVDNFVF VLKQRRKTVK
DITMALYEFM VQEQLQERIA EQEQKFRENG ELALAKEYAQ VYRIVIELID KFVELLGDEQ
VSLNEYCKLL DAGLEEARVG VIPPSIDQVV IGDMERTRLK DIRALLFVGA NDLHLPGNLL
RTGLLSEPDR EQFQNQKLAL APGGKERAYV QKYYLYMNLT KPSEKLDIFY SKVSSDGKNM
RPAYLMQDLR KMYPDMKIIE EEEKSFAERE FTEKLGITCL IRGLQESNGE LDPLWCELYT
WYKKHPEWQQ TVESLLEAGY YRMPMDGLTR QVAEKLYGKY FTDSISRMER FSICAFAHFL
TYGLRLKERP EYDFQSVDFG NVCHRALELY SRKLEHTGES WTEVENKIRK QYIDESVDEA
ITDYGNSVLY SSSRNEYLVE RMKRMLERTI WALTEQLAQG DFAPSAYEVR FTNGKIDRVD
TCEDEDKVYV KVMDYKTGSK EFDVVSLYQG LQLQLMVYIK AAVEREEKRH PGKEIVPSGV
FYYRIQDPLL DGKVMDEILR GTEEEKKEQM EKEMLKVLRP DGLVNLSGEN LKHLQKIQSG
DSVAVPVKYT KSGSLSKTSK VASETDFDTL MRYAQKKVEE IHQKIADGEV AALPYRQGTE
TGCDYCKYRH ICGFDLKVPG YHYRNLEKLS KEEAIQKMTA EVGTGLKQPE KSKKTGMAEK
EEQPDKEKNS KEEQ
//
