ID R5DV63_9FIRM Unreviewed; 579 AA.
AC R5DV63;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=BN462_01366 {ECO:0000313|EMBL:CCX84013.1};
OS Ruminococcus sp. CAG:108.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262950 {ECO:0000313|EMBL:CCX84013.1, ECO:0000313|Proteomes:UP000018037};
RN [1] {ECO:0000313|EMBL:CCX84013.1, ECO:0000313|Proteomes:UP000018037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:108 {ECO:0000313|Proteomes:UP000018037};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX84013.1}.
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DR EMBL; CAXD010000100; CCX84013.1; -; Genomic_DNA.
DR AlphaFoldDB; R5DV63; -.
DR Proteomes; UP000018037; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000018037};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 464..554
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT COILED 308..335
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
SQ SEQUENCE 579 AA; 65639 MW; 6464CA0B3266D141 CRC64;
MALDGIFLRH IISEIEKEAL GARVSQIYQP NREELVFGLR TFSGNKKLLL SARANSPRVN
FCSSTPENPA QPPMFCMLLR KRIGGGKLVG LRQNGCDRVL MLDFECVNEL GDTVMITVVC
EIMGMYSNII IVDSNGVIID SLKRVDLTMS SKRLVLPNIK YELPESQNKL NLLKCSVLDV
CTAVKNLDTE MPLNKALLRT IEGVSPIVCR EIEYKVMEGA TNRIEGVLFD RLAVEIEKLK
SVCSDCSGKP VVVYREDGKP MDFCFMNVEQ YGDFAKVESK ESFSDLLDGF YEARDSRDRM
RVKSQSLTKL LNNTLERLAR KIAKQKSELE RCADREHLRI CGDLLQANIY RIERGAEYVD
VENFYDENNA ILRIKLNPAI SPSANAQKYY KDYRKAKNAE IMLKEQLEKG REELDYINSV
LDTVDRAENE KDLAQIREEL TEQGYLKVQK GKKPRQTTLP PLEFESSDGF KILVGRNNRQ
NDKLTLKTAS KNDMWLHTKD IHGSHVIVVS DGKEISDTAI YEAARLAAYH SKARNSSQVP
VDCTLVRYVS KPNGSKPGMV IYVNNKTLYV KPSQTVEKQ
//