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Database: UniProt
Entry: R5E0M9_9FIRM
LinkDB: R5E0M9_9FIRM
Original site: R5E0M9_9FIRM 
ID   R5E0M9_9FIRM            Unreviewed;       390 AA.
AC   R5E0M9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   SubName: Full=Malic enzyme NAD binding domain protein {ECO:0000313|EMBL:CCX82377.1};
GN   ORFNames=BN462_00512 {ECO:0000313|EMBL:CCX82377.1};
OS   Ruminococcus sp. CAG:108.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminococcus; environmental samples.
OX   NCBI_TaxID=1262950 {ECO:0000313|EMBL:CCX82377.1, ECO:0000313|Proteomes:UP000018037};
RN   [1] {ECO:0000313|EMBL:CCX82377.1, ECO:0000313|Proteomes:UP000018037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:108 {ECO:0000313|Proteomes:UP000018037};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCX82377.1}.
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DR   EMBL; CAXD010000041; CCX82377.1; -; Genomic_DNA.
DR   Proteomes; UP000018037; Unassembled WGS sequence.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 2.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018037};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018037}.
FT   DOMAIN       15    148       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      160    383       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE     36     36       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE     91     91       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       133    133       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       134    134       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       159    159       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   390 AA;  41732 MW;  C6994282A4F202B9 CRC64;
     MDIRKESLKK HYEWNGKIEV VSRVPINSAE DLSLAYTPGV AEPCLEIQKD YDKSFELTRR
     NNLVAVVTDG TAVLGLGDIG PEAGMPVMEG KCALFKEFGD VDAFPICVRS KDVDEIVNAI
     YLISGSFGGI NLEDIAAPRC FEIEKKLKEK CDIPIFHDDQ HGTAVIVAAG LINSLKLVHK
     KLDEIKVVMN GAGAAGIAIA KHLLNMGVKD ITLCDSKGII CKGDPRLNAV KQEMAEITNL
     SHLEGSLADA MKGADVFLGI SAAGCVSEEM VKSMAKDPIL FAMANPTPEI MPDIAKKAGA
     AVVGTGRSDF PNQINNVLAF PGIFRGALDC RASDINEEMK VAASFAIASL VSDEELNADY
     ILPEAFDKRI GKTVAEAVKK AAVETGVARI
//
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