ID R5FWH8_9ACTN Unreviewed; 1949 AA.
AC R5FWH8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Helicase C-terminal domain-containing protein {ECO:0000259|PROSITE:PS51194};
GN ORFNames=BN494_01399 {ECO:0000313|EMBL:CCY05047.1};
OS Eggerthella sp. CAG:1427.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Eggerthella.
OX NCBI_TaxID=1262874 {ECO:0000313|EMBL:CCY05047.1, ECO:0000313|Proteomes:UP000018393};
RN [1] {ECO:0000313|EMBL:CCY05047.1, ECO:0000313|Proteomes:UP000018393}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:1427 {ECO:0000313|Proteomes:UP000018393};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY05047.1}.
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DR EMBL; CAXM010000010; CCY05047.1; -; Genomic_DNA.
DR Proteomes; UP000018393; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 1469..1634
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 393..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 595..629
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1173..1200
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1669..1696
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 393..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1949 AA; 220655 MW; 18DEA1EA85422D6D CRC64;
MAFNRKERLR GNIEAIRTAF ALDKERRAAT PEEREIISRY CGFGGLKCIL NPASSLTDAA
DWAKSDLELF PMTVELHRLI RDNSKDDAEY KRYIDSLKSS VLTAFYTPKE VTDTIASVLK
EYNVTPSKVL EPSAGMGAFI SSVKEQAPQA DVMAFEKDLL TGKLLSYLYP DEKIRVEGFE
KIEKPFNGSF DLAISNVPFG EVAVFDPAFE TGGNPAYKSA QRAVHNYFFL KGLDTVRDGG
IVAFLTSQGV MNSQRNEAIR LEMLKGAHLV SAVRLPNNLF TENANTEVGS DLIILQKDTR
KEGLSEDEKL FTETGTLHGV PTNRYIIRHE EQIVHTKTEL DTDPYGKPAM VYTHEGGVQG
IAEDLRKLLD DNLHMRLVMR LYSGGIRDAR LREQSEAVRQ EPQEAEIKIP ETTERNKVGN
VPVSETSETP ESSAPADEKP EIEAPAMTLF DLLGITAEEQ RQAQPKPVKK KQPKSNGKST
AAKLNKSATP SPNLFSRSNV NQKAPATDTA SSAQPETMTE EEARQEAVYA SLDWDENPPI
NGFYETMMDL GAEGRARLRR IAREEKEAQP DLFAAQEQTV PEDAIPVYPI EDGFKAELQR
RIDGVERQMR EEEAALPQEE RQRKHEEEMQ PRPFTGVMEA HLKEGSLVRV NTVGVRYQIG
VLKDVTRYDA TFQPLDLQEY QKEKADLYIQ IRNSYERLYA YEAEHREAHT LHRENLNTHY
DEFVMRYGNL NAKQNAGMIL MDAAGRDILS LERGENGLFV KADIFDHPVS FSNEESVSVE
TPEDALTASL NRYGGVNMEY MCELCGNSEA ELTEALKGRI YYNPMENCYE IKDRFIAGNV
VSKAERVGRW VQENKEGETA HPMLPAAEES LEALQKSIPE PILFDELDFN FGERWIPTGI
YSSYMSYLYG TDIKIAYVDS VDEFTVSCGY KNVKIYDQFA VKGYYKRYDG MNLLKHALHN
TVPDIYKSIG KDDHGNDIKV RDSEAIQLAN AKIDEIRSGF TEWLEAQSPE FKQRLADMYN
RKFNCYVRPK YDGSHQTFPD IDLKALGRQY GINEVYPSQK DCVWMLKQNG GGICDHEVGT
GKTLIMCMAA HEMKRLGLVH KPMIIGLKAN VAEIAECYRT AYPNARILYA SEKDFAAANR
VRFFNNIKNN DYDCVIMSHD QFGKIPQSPE MQQKILQAEL DTVEENLEVL KQQGKDISRA
MLKGLEVRKH NLAAKLQGIA YAIEHRTDDV ADFGQMGIDH IFVDESHQFK NLMFNTRHSR
VAGLGNQEGS QKALNMLYAI RTIQERTGKD LGATFLSGTT ISNSLTELYL LFKYLRPKEL
ERQDIRCFDA WAAIFAKKTT DFEFNVTNNI VQKERFRYFI KVPELAMFYN EITDYRTAED
VGVDRPQKNE ILHNIPPTPQ QEEFIGKLME FAKSGDATIL GREKLSDSEE KAKMLIATDY
ARKMALDMRM ISPDYEDHPD NKASHCAKMI AEYYRKFDEQ KGTQFVFSDL GTYQSGQWSV
YSEIKRKLIE DYGIPAHEIR FIQECKSEKA RKSVIAAMNE GAVRVLFGST SMLGTGVNAQ
QRTVAVHHLD TPWRPSDLAQ RDGRAVRKGN EIAKMFAGNN VDVIIYAVEK SLDSYKFNLL
HCKQTFISQL KSGAMGARTI DEGAMDEKSG MNFSEYMAIL SGNTDLLDKA KLEKKIAALE
GERKSFAKAR NEAEGKLNEK TKEFNNNKVI IERMTEDYNT LLSRAETDKD GHKINRIQLD
GLEATDDKSV GTRLQEIARN ATTGGLYTRI GEVYGFPIYV ISETALKDGV SAIQNRFVVE
GNYKYNYNNG QLAMADTKAA AMNFLNALER IPNIVEQYKS KNEVIERDLP ILQEVAGKTW
RKEDELKALK SELAALDRKI QLELAPSTPE VAEKKNEGQQ TKPMMENASQ IHNRENERNF
TGNFVADHIA IIQSGLQLKD ENRAKGIKL
//
