ID R5GDV4_9PORP Unreviewed; 746 AA.
AC R5GDV4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Guanosine-3' 5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:CCY10676.1};
GN ORFNames=BN460_01308 {ECO:0000313|EMBL:CCY10676.1};
OS Porphyromonas sp. CAG:1061.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas; environmental samples.
OX NCBI_TaxID=1262916 {ECO:0000313|EMBL:CCY10676.1, ECO:0000313|Proteomes:UP000018064};
RN [1] {ECO:0000313|EMBL:CCY10676.1, ECO:0000313|Proteomes:UP000018064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:1061 {ECO:0000313|Proteomes:UP000018064};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY10676.1}.
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DR EMBL; CAXO010000192; CCY10676.1; -; Genomic_DNA.
DR AlphaFoldDB; R5GDV4; -.
DR Proteomes; UP000018064; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CCY10676.1}.
FT DOMAIN 400..469
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 669..742
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 746 AA; 85758 MW; ED4938418C1D7B8A CRC64;
MQSEQDYGVV VQSAFDQLLA DYLNSNHRKR TDVICKAFNL ARAAHEGAKR KSGEPYILHP
IAVASICCNE IGLGSTSIAS ALLHDVVEDT EYTVQDIRDM FGPTIARIVD GLTKLSGEIL
AEMMMGKENA SAQLENIRHL LLTANNDMRI VIIKIADRLH NMRTLGSMPL AKQAKIASET
RLFYAPLAER LGMYDIMSEL NDLSLKYDHP QQYIEIQEEI ERSGAKRSKL FQLFYAEVRE
DLEATGLVYE IQHRMKGIYS IWKKMTTKQL SFDEIYDLFA IRIVFEPTRN DTEYDDCFRI
YRAISRHFRI KDDRTRDWLT KPKENGYQAL HITVMGPLGE WVEVQIRSKR MHEMAERGLA
AHWRYKQHPG EIDEIEQNIL NNVRVLLSNP GPSASDDYET MMYKFTTEEM LIFTKMGDQL
RVPQGYTVLD FAYELGREYG DHCLGAKVNH VMVNIDYPLH SGDQIEVLTA SKVQPREEWL
EYVTSPQAKR YIRNYLSNVR TKQIQRGRNL LEAHLHREGY ALGDLVPNFG HVLSYPTPEH
LFLAVQSGEV SLDDDLTKQL IEDRHKGNRM SEDRQLWLDS DETQVPSIAP EDRKKLYTLE
ARDGRRNYIR SLCCKPICGE EVDGILNQKD QVEVHKKSCS IAMQLKATYG DRIVAVAWGP
HIHSNFGVTL EVEGVNQDGF VHNVLGTIRD LRVPLIEIHF SSSIDRAIGT LRIRIPNITE
LNYLIRRLKD ENDILHIQIL TNKPIL
//