ID R5HGH4_9MOLU Unreviewed; 737 AA.
AC R5HGH4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN ORFNames=BN802_00160 {ECO:0000313|EMBL:CCY27214.1};
OS Acholeplasma sp. CAG:878.
OC Bacteria; Mycoplasmatota; Mollicutes; Acholeplasmatales;
OC Acholeplasmataceae; Acholeplasma.
OX NCBI_TaxID=1262686 {ECO:0000313|EMBL:CCY27214.1, ECO:0000313|Proteomes:UP000017930};
RN [1] {ECO:0000313|EMBL:CCY27214.1, ECO:0000313|Proteomes:UP000017930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:878 {ECO:0000313|Proteomes:UP000017930};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY27214.1}.
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DR EMBL; CAXX010000004; CCY27214.1; -; Genomic_DNA.
DR AlphaFoldDB; R5HGH4; -.
DR STRING; 1262686.BN802_00160; -.
DR Proteomes; UP000017930; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000017930}.
FT DOMAIN 341..490
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 352..356
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 737 AA; 85750 MW; AF3A8BD84061BF40 CRC64;
MKHYIKGNYR KSIFKTDQGY VIGLFKVRET NSENLADFVN KTITFTGYFH ELNEDDLYVF
YGEDIFHPRY GLQFQVTEYE RLTPKDKDGL IEFLSSDLFK GVGEALATNI VNELGENAIE
KILENEEILY DIPKLTIKKA HKIYETLNKY ESSHQVIIYL TELGFNMKDS LNIYNTYKEQ
TINNIEYNIY KLIDDINGIS FVKVDEVAKK FNIKEDDERR IKAAIIYVMN KLVYEKSDTY
LEYNEIYNGV YGYLRLNLDN DLFNRLLSEL EQEFKIVIED DRYYLKEMYE AEENIANKIK
IITNLNETKY KNLDEKINYI EEINNLKYSE NQKKAIKSAL IDNLLIITGG PGTGKTTIVK
AICQLYMELN DLDFDNAVNN IALLAPTGRA SKRLSESTNL PAYTIHRFLK WNQEKNEFAV
NEYNKNVHKL IIIDEVSMLD TLLLDSLFKG LNDNIKVILV GDHNQLPSVG PGQILKDLIE
SDVIPIVYLD LLYRQDENSY ITTLAQEIKN DSLSENFLET RSDYTFLRCN SLSLKQNLIN
LCEQIISKGY DYKRVQLMAP MYKGENGIDV LNSELQNVFN PAAPTKKEIK YGDVIFREND
KILQLVNMPE ENIYNGDIGV IKYILTENTK SKRTEIYIDF DGNVVRFLPK DLIKIKHGFI
ISIHKSQGSE FEMVVMPICK SYKRMLYRKL IYTGITRAKR KLILIGEDDA FIYSVKNNSE
MSRKTSLKEK LMNKILN
//
