ID   R5HXR7_9BACT            Unreviewed;      1206 AA.
AC   R5HXR7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Papain family cysteine protease {ECO:0000313|EMBL:CCY34638.1};
GN   ORFNames=BN796_00140 {ECO:0000313|EMBL:CCY34638.1};
OS   Alistipes sp. CAG:831.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC   Alistipes.
OX   NCBI_TaxID=1262698 {ECO:0000313|EMBL:CCY34638.1, ECO:0000313|Proteomes:UP000018094};
RN   [1] {ECO:0000313|EMBL:CCY34638.1, ECO:0000313|Proteomes:UP000018094}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:831 {ECO:0000313|Proteomes:UP000018094};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
CC       {ECO:0000256|ARBA:ARBA00008455}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCY34638.1}.
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DR   EMBL; CAYB010000013; CCY34638.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5HXR7; -.
DR   STRING; 1262698.BN796_00140; -.
DR   Proteomes; UP000018094; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02619; Peptidase_C1; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR   PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000313|EMBL:CCY34638.1};
KW   Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:CCY34638.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018094};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        859..876
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        888..909
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        929..947
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          476..706
FT                   /note="Peptidase C1A papain C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00645"
FT   COILED          404..438
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          748..803
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          954..988
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1206 AA;  137842 MW;  1C473B6F28C4F208 CRC64;
     MEHFAHIFIG KEFAEIVSNI GRKVYKYGGE ELLSSVNQFV VDDGRVRQLL YPEGAIDIKD
     MIQHSSLQLE WRELGRLTDN PEDDKDLFLN GIFNQILRVG NVGANASLYT MIHFPLYKSE
     ALESAEYLYR IIKLAGRPVD LDFMGFCDDM ASIIEPDYVI TSPSKNQVEK YKAFRDAESI
     GYSTHFIVMQ NASQNGISLG LNADSFATIL SHFSILCAGY YHEMFPNTVE YMDVVAFGFS
     TLCLDKYLYA EYLLSKSMLN AMDAAHVNDR EVDVNNAYVV VNNMLKDKAT LLSTLFQQLD
     GHRNSEADDE YQDIQKKFTD DVQEIVDRCK DTLKKQSAIT MQAAILAVCL AKTDCELFSE
     TIFTQDIVTV DKLFDEPIEY YINNDHAHYY KLGGENPVNP IQKLKELDAR LINSETAIRN
     LKNDLETLNK QIGDSEKVKE FYVEDGYIHF KNQKFRLLPS VEQVPLAETY TPHEVKVRSL
     DMRSKFTSVK NQGQQGSCLS FALTSIFEYV MHLNAAQEFD LSEAFLYYNA RDLDGDGGVN
     NDSGSRFKPS IDALIKYGIA LESVWPYNDQ VYSKKPSDEA YADAAGRKLV SAMNVNSKVS
     DIKSALVDNC PVAASFTLTK SFFEFGRAGG YIPMPGDEEI ASVIEQESEE DLHSCHAMVI
     VGFSDDLQMF IVRNSWGTDW GDNGYCYIPY SYVEHEGLLN YACIFTEIEK LVTCPDNMEV
     MPLTIDSSDL HIQYAVKKNE LYIEEHTAEQ LRNDRKELRV YFESLKQMYC NPNQRDCFID
     ANKALLTAEQ ESLKEKISAK EAECDANDEK MNKYKKDLLF RSASFLTGTV LLAVMYKQFV
     DFLHVSSADP DFQFTFKPFL VWIIIFAILA IVSWLLRKKS FVKSFWMSIW GVVGVLMAKA
     ISRLVSYFVG SGTLVSYFGP TDFFHKIDGG QFLWLLAVFA VAIIITYRNG HIVWRDWRDE
     RDRINAEIDK LHNEINVKEK EKRFLKLKTF SAWTLITKLQ GLHTEFYSNY ANLISLINNF
     RVWYNELKTK GDDISLHTVF PETSLLSAEL LDEFFDRSLK NDPELCVDLC ANISQYNITS
     ESLSKYKETL MRQVIDSLLS RKEIREFDIS NHIANNTFAD IAMEVNRKLV TALDEQSGIF
     LNVNSQQRGV IVPSTAVFAP SLGKYRDSIR KKLGKYSEPY YESAGKYCLT FLKTATVWFQ
     ECVNFK
//