ID R5JVN4_9FIRM Unreviewed; 512 AA.
AC R5JVN4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Putative 5-methyltetrahydrofolate--homocysteine methyltransferase {ECO:0000313|EMBL:CCY53046.1};
GN ORFNames=BN781_00115 {ECO:0000313|EMBL:CCY53046.1};
OS Coprococcus sp. CAG:782.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Coprococcus.
OX NCBI_TaxID=1262863 {ECO:0000313|EMBL:CCY53046.1, ECO:0000313|Proteomes:UP000018002};
RN [1] {ECO:0000313|EMBL:CCY53046.1, ECO:0000313|Proteomes:UP000018002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:782 {ECO:0000313|Proteomes:UP000018002};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the vitamin-B12 dependent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00010398}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY53046.1}.
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DR EMBL; CAYJ010000013; CCY53046.1; -; Genomic_DNA.
DR AlphaFoldDB; R5JVN4; -.
DR STRING; 1262863.BN781_00115; -.
DR Proteomes; UP000018002; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro.
DR CDD; cd02070; corrinoid_protein_B12-BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR011005; Dihydropteroate_synth-like.
DR InterPro; IPR036594; Meth_synthase_dom.
DR InterPro; IPR000489; Pterin-binding_dom.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR Pfam; PF00809; Pterin_bind; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
DR PROSITE; PS50972; PTERIN_BINDING; 1.
PE 3: Inferred from homology;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CCY53046.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018002};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCY53046.1}.
FT DOMAIN 29..294
FT /note="Pterin-binding"
FT /evidence="ECO:0000259|PROSITE:PS50972"
FT DOMAIN 295..389
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 390..512
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 512 AA; 55510 MW; A6A18AFB755FA1D1 CRC64;
MKIPQVSTEH KRCISSERAT RFIELDAPFM VVGERINPTG KKKLQAELRE GKLDLVMSMA
EEQVEMGASI LDINVGMNGI DEKEMMLRVV GEVSQAVNLP LCIDSSYPSV IEAALRTYPG
RALINSISLE EVKIREILPI AKKYGAMFIL LPLSDEGLPK DRNEKEANIN AVLFKAFNDG
FTKEDIVVDG LVATVGAQKN AAVATLETIE YCHDMGLATI CGLSNISFGL PERTFVNAAF
LSMAISKGLT MAIANPSQAL LMNSAYATDM LLNKEGSDVK YINNVRAVSA SPASDAPKGD
NDIQGSQIFV DVVKGNKRNI VEHVNAELAS GRNPEEMIND DLISGINKVG ELFEKKKYFL
PQLIASAETM EMAINIVSPL VPKKNDGVAM PTLVIATVEG DIHDIGKNLV VLMLKNYGFN
VIDMGKDVPA EEIVDMAVKE NASLIGLSAL MTTTMVRMKD VVNLVKERNL DIKVVIGGAV
ITQSYADEIG ADGYSKDAAD SVVLVKKLLN IE
//