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Database: UniProt
Entry: R5JVN4_9FIRM
LinkDB: R5JVN4_9FIRM
Original site: R5JVN4_9FIRM 
ID   R5JVN4_9FIRM            Unreviewed;       512 AA.
AC   R5JVN4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Putative 5-methyltetrahydrofolate--homocysteine methyltransferase {ECO:0000313|EMBL:CCY53046.1};
GN   ORFNames=BN781_00115 {ECO:0000313|EMBL:CCY53046.1};
OS   Coprococcus sp. CAG:782.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Coprococcus.
OX   NCBI_TaxID=1262863 {ECO:0000313|EMBL:CCY53046.1, ECO:0000313|Proteomes:UP000018002};
RN   [1] {ECO:0000313|EMBL:CCY53046.1, ECO:0000313|Proteomes:UP000018002}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:782 {ECO:0000313|Proteomes:UP000018002};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the vitamin-B12 dependent methionine synthase
CC       family. {ECO:0000256|ARBA:ARBA00010398}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCY53046.1}.
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DR   EMBL; CAYJ010000013; CCY53046.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5JVN4; -.
DR   STRING; 1262863.BN781_00115; -.
DR   Proteomes; UP000018002; Unassembled WGS sequence.
DR   GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0042558; P:pteridine-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd02070; corrinoid_protein_B12-BD; 1.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR   Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR   InterPro; IPR003759; Cbl-bd_cap.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR036724; Cobalamin-bd_sf.
DR   InterPro; IPR011005; Dihydropteroate_synth-like.
DR   InterPro; IPR036594; Meth_synthase_dom.
DR   InterPro; IPR000489; Pterin-binding_dom.
DR   PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR   PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF02607; B12-binding_2; 1.
DR   Pfam; PF00809; Pterin_bind; 1.
DR   SMART; SM01018; B12-binding_2; 1.
DR   SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR   SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
DR   SUPFAM; SSF47644; Methionine synthase domain; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
DR   PROSITE; PS51337; B12_BINDING_NTER; 1.
DR   PROSITE; PS50972; PTERIN_BINDING; 1.
PE   3: Inferred from homology;
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:CCY53046.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018002};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCY53046.1}.
FT   DOMAIN          29..294
FT                   /note="Pterin-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50972"
FT   DOMAIN          295..389
FT                   /note="B12-binding N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51337"
FT   DOMAIN          390..512
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
SQ   SEQUENCE   512 AA;  55510 MW;  A6A18AFB755FA1D1 CRC64;
     MKIPQVSTEH KRCISSERAT RFIELDAPFM VVGERINPTG KKKLQAELRE GKLDLVMSMA
     EEQVEMGASI LDINVGMNGI DEKEMMLRVV GEVSQAVNLP LCIDSSYPSV IEAALRTYPG
     RALINSISLE EVKIREILPI AKKYGAMFIL LPLSDEGLPK DRNEKEANIN AVLFKAFNDG
     FTKEDIVVDG LVATVGAQKN AAVATLETIE YCHDMGLATI CGLSNISFGL PERTFVNAAF
     LSMAISKGLT MAIANPSQAL LMNSAYATDM LLNKEGSDVK YINNVRAVSA SPASDAPKGD
     NDIQGSQIFV DVVKGNKRNI VEHVNAELAS GRNPEEMIND DLISGINKVG ELFEKKKYFL
     PQLIASAETM EMAINIVSPL VPKKNDGVAM PTLVIATVEG DIHDIGKNLV VLMLKNYGFN
     VIDMGKDVPA EEIVDMAVKE NASLIGLSAL MTTTMVRMKD VVNLVKERNL DIKVVIGGAV
     ITQSYADEIG ADGYSKDAAD SVVLVKKLLN IE
//
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