ID R5JWC2_9CLOT Unreviewed; 547 AA.
AC R5JWC2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Glycosyl hydrolase family 43 {ECO:0000313|EMBL:CCY58715.1};
GN ORFNames=BN743_01912 {ECO:0000313|EMBL:CCY58715.1};
OS Clostridium sp. CAG:632.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262830 {ECO:0000313|EMBL:CCY58715.1, ECO:0000313|Proteomes:UP000018242};
RN [1] {ECO:0000313|EMBL:CCY58715.1, ECO:0000313|Proteomes:UP000018242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:632 {ECO:0000313|Proteomes:UP000018242};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY58715.1}.
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DR EMBL; CAYL010000142; CCY58715.1; -; Genomic_DNA.
DR AlphaFoldDB; R5JWC2; -.
DR STRING; 1262830.BN743_01912; -.
DR Proteomes; UP000018242; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd18620; GH43_XylA-like; 1.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43772:SF2; BETA-1,4-XYLOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR43772; ENDO-1,4-BETA-XYLANASE; 1.
DR Pfam; PF04616; Glyco_hydro_43; 2.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00022651};
KW Reference proteome {ECO:0000313|Proteomes:UP000018242};
KW Xylan degradation {ECO:0000256|ARBA:ARBA00022651}.
FT SITE 154
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 547 AA; 62637 MW; DAF19EEBDD1217B4 CRC64;
MKGQNKGTQK QQVYNPFLPL NEYIPDGEPH VFGDRVYHFG SHDKEGGYTF CMLDYVAYSA
PVTDLSDWRY EGVIYQAKQD PRYPDPQYMY APDVVQGNDG RYYLYYCMGG DYGQGGYQGP
IGVAVCEEPA GQYEYLGVVK NPDGSPMMKY ICFDPAALND NGTIRIYYGT QYDYEEREDF
MENDSYMQEE IEMFGRSREE ILSYPDSIMG ACMVVLEDDM LTVKEEARHI IPYRVKGTGF
EAHPFFEGSS MRKVGDRYYF VYSSWQNHEL CYATSRYPDR DFTFGGTIVS NGDIGYQGRT
VDEKLNMTGT THGSIVEING QWYVFYHRLT HKSDYSRQAC AEKIQILEDG RIPQVEITSC
GLNDGPLKGE GRYPAVIACN LTNGHMPHGS NSIFQIPFPN VTNLGEERFI AEIEDGTLIG
YKYFECSGVT AFGISARTET DANRVVYQGP LRTDERSMND DNFLQYHKEE KQSLQEKAGQ
KDMDAYIELF TDPEQKISVG MLDVSRLPET WTDIRTEFRI PDGVYGIYLV YHGAKKLQLR
EIFLETF
//
