ID R5L5F0_9FIRM Unreviewed; 1216 AA.
AC R5L5F0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN508_01453 {ECO:0000313|EMBL:CCY68262.1};
OS Eubacterium sp. CAG:161.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1262881 {ECO:0000313|EMBL:CCY68262.1, ECO:0000313|Proteomes:UP000018318};
RN [1] {ECO:0000313|EMBL:CCY68262.1, ECO:0000313|Proteomes:UP000018318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:161 {ECO:0000313|Proteomes:UP000018318};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY68262.1}.
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DR EMBL; CAYQ010000009; CCY68262.1; -; Genomic_DNA.
DR AlphaFoldDB; R5L5F0; -.
DR STRING; 1262881.BN508_01453; -.
DR Proteomes; UP000018318; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000018318}.
FT DOMAIN 1..468
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 484..776
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1216 AA; 139135 MW; 03A7F8B68581C29C CRC64;
MKWTDKQLDV INTRNRNILV SAAAGSGKTA VLVERIINMI TDEESDVNID ELLVVTFTRA
AASEMKERVR AALEEAIEKN PDNENIIKQL SLIHNADIST IDSFCAKIVR ENFDKIDLDP
NFRIADETEI KMIKADVIGE MLEDYYLEAD EKFMSLAKQY SAGRLKDNIE ELIEQLYKNA
CGHSDPEKWV KNSGNIYNIK TLEEFENSEL LGEIVNFAKL ELDGILEDLN TALKISMETD
GPGCVDGLTQ LMESISEIQK QNNYNKMRLA FRGVKSVTLR GAKGCDEAKK KQVQDIKKKA
MDRLGKLESE LFEQTVEEMA SDIIKSHDSV SMIIKLTLDF MKRFADKKGE KGIMDFNDQA
HFALKILLSE DEKGNVYPTD VARQMAENYK EIMIDEYQDS NYVQEDILNS VSKGQGVNNI
FMVGDVKQSI YRFRQAEPGL FLHKYDTYSQ DLTKDCCKII LDKNFRSRRE VINSVNYIFN
YIMTEKVGGI NYKNGNGLTC GAKYDESINK QDNSTEIFMV EGEGREDEAD FVAKKILEIT
DPENGLKITE EGQNKRRVKY SDITILLRSL KGVSDIYLQA LEDNGIPAVA DSKTGYYRTI
EVRTVVSALS VIDNPYQDIP LATILISPMF SFTENELAVI KAENICEYLY DNLLLYKETG
SDAEIKVKVK GFLDFLDDYR KRSVYIKVYE LIEQLVNETG YDYYISSMPG GKRRHVNIEA
LKEKAVAYEN ISYKGVFNFI RYIEKLQYLD SDDGEAGISQ ENDNTVKIMS IHKSKGLQFP
VVFLCDTNGG GRNDTDKIVV DDNGNIGVDM IDENLKVKSP TIVKRLIRRK NKQEDMAERL
RILYVALTRA KEKLIITGVT KKLTKTISDL KESMYNVKDE MSYSNIVNAP NMFTWIGKTV
AKNKAFDTIA EREFNGTKAR DEMYNAEADI VINTVEAEDM LYQEGKALIK DEIDSKKLDR
IFNLKADNGD DVKKKFDFTY QYLDDVTLHS KASVTEIKKQ SMAYVEEIDG NQEFHKETEV
PEIIPDFARE DISGNETLYG AERGTAYHRV FELLDFDMEE YTIDTVKKMI ESFVDKGLMT
KEQAGCIYYK DIISFTKTDL FNRMKKAYKK GKLYRERKFL LGVKANEING RSNSDETMII
QGIIDVCFEE DGEFVIADYK TDKVKTMEEL DKRYHVQLEC YKLAIERISQ INVKEMIIYS
VTLGKEAEIK KEDKGE
//