ID   R5MG20_9FIRM            Unreviewed;       982 AA.
AC   R5MG20;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:CCY90463.1};
GN   ORFNames=BN519_00441 {ECO:0000313|EMBL:CCY90463.1};
OS   Eubacterium sp. CAG:180.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262882 {ECO:0000313|EMBL:CCY90463.1, ECO:0000313|Proteomes:UP000018411};
RN   [1] {ECO:0000313|EMBL:CCY90463.1, ECO:0000313|Proteomes:UP000018411}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:180 {ECO:0000313|Proteomes:UP000018411};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCY90463.1}.
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DR   EMBL; CAZC010000022; CCY90463.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5MG20; -.
DR   STRING; 1262882.BN519_00441; -.
DR   Proteomes; UP000018411; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018411}.
FT   DOMAIN          510..587
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   982 AA;  113502 MW;  E268BAA6F1F31009 CRC64;
     MAHIKVVRRS MRPEEWNDLR FGWLKRYIIN DKLPIDNIVI KDARQVTENN YEFYSDEFRP
     LKKGDLYFTP DGTAFIKAET EVPDSLKNKE LWLYLKTAAE IIVKANGKFV GGIDPNRDRV
     LLTPYIGTPD KIKFEMQGYN RSKPDDERNP ESLAVRGCRQ IFNGAYLVTI DRDVQSLVYD
     IETLLDIAKS ELFNEDYRKF VNTELNNALN LIDFDTDSRP TGIKEAKKYV NDVIFANRDY
     KGSGDVALVA HSHLDIAYYW RRIHAVQKNL RTVLIQLRLM DRYPEFKYTH TQAYTYESLK
     QYYPEVFEEL KKRVKEGRFE PVGAMYIEPD CNIPSAESLI RQCFYGQLFF RENFGKTINN
     CWLPDVFGNS WILPQILKKC GVDYFVSNKM STWNDTNRFP HNNFIWKGID GSEVYACVPP
     THFITWNMPS QIQENWEAYQ DKNSGGQTMS MFGYGDGGSG VTEEMLEVMR RFDKISVMPK
     TKHMGGAEFL EKNLKGNTSL AKWDGELYLE MHRGTFTTKA NLKKLNRRLE YKIREAEIIS
     TLRAMSGFDY PGEKLKECYK KLLINQFHDI LPGSHINPVY NDALADYVYV DKTLSGIIGY
     GEAYFNSLNF KRKELTFFED EDGSETRFGK KGFWTVPNIA PLDCTVIEKP DEEFSDEWCI
     VNGNSAETPF YKIKFASDGS ISGLYDKKLD REWVNGVFNR LEIYEDNPGV YDAWDILPNY
     TDKIIPLKVV SPLKLTEKSG EACSFRVTLG TENSKWERII RIFRRSPKIE VENNVDWHEK
     HKLAKVLFSP NVLSREVLCD TGAGFIARET HKNTSWQSAR FECCHHKWFD VSETDGGIAV
     INDSKYGIGI SENTLSLSLL RATERPDPES DIGKHSFAYL IYPHSGSAVD AHINDIAFEF
     NIPLTRADVS CQNTFDGMFL QAMKLSEDGE MVVVRLSEQN GRRGKMKFPQ QVYVLNMLED
     KLYLTDEIDY KPFEIITIGI LR
//