ID R5NB96_9FIRM Unreviewed; 671 AA.
AC R5NB96;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Late competence protein ComEC (Membrane metal-binding protein and hydrolase of the metallo-beta-lactamase superfamily) {ECO:0000313|EMBL:CCY94801.1};
GN ORFNames=BN804_00033 {ECO:0000313|EMBL:CCY94801.1};
OS Firmicutes bacterium CAG:884.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1262990 {ECO:0000313|EMBL:CCY94801.1, ECO:0000313|Proteomes:UP000018073};
RN [1] {ECO:0000313|EMBL:CCY94801.1, ECO:0000313|Proteomes:UP000018073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:884 {ECO:0000313|Proteomes:UP000018073};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY94801.1}.
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DR EMBL; CAZD010000055; CCY94801.1; -; Genomic_DNA.
DR AlphaFoldDB; R5NB96; -.
DR STRING; 1262990.BN804_00033; -.
DR Proteomes; UP000018073; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Hydrolase {ECO:0000313|EMBL:CCY94801.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..122
FT /note="DUF4131"
FT /evidence="ECO:0000259|Pfam:PF13567"
FT DOMAIN 152..391
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 423..625
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 671 AA; 78581 MW; D266610399F8D75C CRC64;
MKKLKIILGL SLIIILIFNL NNKSKYNDRA TYIEGIIDKY KFDGSKLSLE VLGKERIVCN
YYFDTIEEKE SFKKKIKYGQ TIYLEGKINI PNENTNFKLF NYRKYLLSKK IYYVFNIEKI
EIKNNINLLY KIKNHLVTKL DKFNSPYLYA FILGDTNYIE EDIKESFQNN GISHLLAISG
MHITFLFNGL YNLLNKIKKR KTNIIIVAIL LFIYLFLVGF STSSIRAGTM FIILKIKKIK
PYKLLLTIFF LFLIYNPYLI FSQSFLLSFV VTFYLIIFKD LIKGNYFKKT LMTSLIAFIA
GTPIIIYNYN SINLLSILLN LLFVPLISYI IFPLSFLSLL FNLKKTYTFF INIFEKTSLL
FEKISLSLTL KDISIFILIY TILGIFVLIK LTRNKRKYLI LYFIIFIIHS NLFNFSLNLT
MLDVGQGDAI LIEFPFNRGN VLIDTGGKEY FEEWKKPKYS ISKSITIPYM KKKGIKELEY
LIISHGDYDH MGEAINLINN FKVKEVIFNC NSYNDLENNL ISLLNNKKIK YKKCIKNIDK
YGFKFLDTEY YSNENDSSNI IYFNYKNVQF LFMGDASYKR EKEIIKKYNL KNIDFLKVGH
HGSASSSNRL FINSINPKNS LISVGKNNMY GHPKEKVLDI LKNSNIYRTD LNGSIEIKVN
KKGYKIRSCL S
//