ID   R5NQZ8_9BACT            Unreviewed;       616 AA.
AC   R5NQZ8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:CCZ06273.1};
GN   ORFNames=BN783_02249 {ECO:0000313|EMBL:CCZ06273.1};
OS   Odoribacter sp. CAG:788.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Odoribacteraceae;
OC   Odoribacter.
OX   NCBI_TaxID=1262909 {ECO:0000313|EMBL:CCZ06273.1, ECO:0000313|Proteomes:UP000018100};
RN   [1] {ECO:0000313|EMBL:CCZ06273.1, ECO:0000313|Proteomes:UP000018100}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:788 {ECO:0000313|Proteomes:UP000018100};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ06273.1}.
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DR   EMBL; CAZK010000010; CCZ06273.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5NQZ8; -.
DR   Proteomes; UP000018100; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR017790; Penicillin-binding_protein_2.
DR   NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018100};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        9..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          50..214
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          252..572
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   616 AA;  69705 MW;  30F2B20890BA2F73 CRC64;
     MNKFSHRKAV ISGLIVFVFG IYIIQLFKLQ VIDESYKLSA INNSQRVETQ YPARGLIYDR
     NHKLLVYNQA AYDLMVIPRQ VKNFDTLELI SILGIPKEVL VKNMEKCKRY SRYKASILIS
     QITDNKYAKL QEKLYKYPGF FIQTRTLRKY NVAHSADVFG YIGEVSQSQI EKDSSYTSGD
     YIGVNGLEKS YEKILRGTKG KRILLVDNYN RIKGSYKNGE YDIPAVVGGD LTTTLDIDLQ
     EYAYRLMQNK KGGIIAIEPS TGEILLKVSS PGYDPQFLVG LERSENYRKL QQDPNLPLFD
     RTVTATYPPG SIFKTIQGLI GLQEGVITPA TQYECHRGNS FNGQFMKCHG HASPLDLKGG
     IQNSCNPYFV NVFRRILENN KYANVREAYG KWRDYVLEFG LGQRICPDFM NESSGSIPTQ
     AYYDKVFRTH NWYYTYIMSL SIGQGELLIT PLQMANIVTC IANRGSYLTP HIVRPADPEH
     RARIVRHDLN IRKEYFDVIA DAMEEAVKGG TARVAACDSV TVCGKTGTIQ NPHGLDHSAF
     FAFAPKVNPK IAILVYVENG EWGSTYGAPI AGLLIEKYLT GKISSRKMAL EKKMLEADLI
     HTPVKKTTDK REEAED
//