ID R5NZ18_9BACT Unreviewed; 693 AA.
AC R5NZ18;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=BN471_00752 {ECO:0000313|EMBL:CCZ02082.1};
OS Paraprevotella clara CAG:116.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Paraprevotella.
OX NCBI_TaxID=1263095 {ECO:0000313|EMBL:CCZ02082.1, ECO:0000313|Proteomes:UP000017958};
RN [1] {ECO:0000313|EMBL:CCZ02082.1, ECO:0000313|Proteomes:UP000017958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:116 {ECO:0000313|Proteomes:UP000017958};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ02082.1}.
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DR EMBL; CAZH010000093; CCZ02082.1; -; Genomic_DNA.
DR AlphaFoldDB; R5NZ18; -.
DR Proteomes; UP000017958; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CCZ02082.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000017958};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..141
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 693 AA; 77056 MW; E3522CC52A4B9258 CRC64;
MIAVIGEKPS VARDIARILG ANEKQDGYLS GNGYLVTWAF GHLVGLAMPE AYGIQSFRRE
SLPIIPDNFQ LTPRQVKAEK GYKADPGALK QLKVIKEVFD QSDKIIVATD AGREGELIFR
YIYQYIGCNK PFVRLWISSL TDKAIREGLQ NLKAGSLYDN LFLSAQARSE ADYLIGINGT
QALSVAAGQG IFSLGRVQSP TLAMICTRFL ENKNFVPQKY WQLKLQTTKN NVTFTALSTE
KYDTQQPAID TLQRIKDAET VQVKTIERKE VNQEPPLLYD LTTLQKEANT KLNFSADKTL
SIAQKLYEGK LISYPRTGSR YIPQDVFEEI PERFINLEQY ARFAGYAAGM KGKSLNSRSV
NDGKVTDHHA LIVTENLPGK METDEQAVYE LIAGRMLEAF SEKCVKDITS VTLECAGSLF
TVKGSVTKSA GWRAAFGEKE ETEDNTTLPA IQDGDSLPLS AIELLEKQTK PKPLHTESSL
LSSMETAGKE LENADMKASM KDMGIGTPAT RAAIIETLFT RQYIVREKKN LVPTEKGLAV
YNIIRDKKIA DVEMTGMWEN TLAKIESGEM NPDTFRKGIE VYARQITAEL LDVQLSFASG
SGCICPKCKT GRILFYPKVS KCSNVDCSVT IFRNKSEKQL TDKQITELVT TGKTGLIKGF
KSRNGKVFDA SLAFDDQFNV TFVFPEKKGK PKK
//
