ID R5P8L2_9BACT Unreviewed; 787 AA.
AC R5P8L2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN ORFNames=BN465_02047 {ECO:0000313|EMBL:CCZ12815.1};
OS Prevotella sp. CAG:1092.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262919 {ECO:0000313|EMBL:CCZ12815.1, ECO:0000313|Proteomes:UP000017987};
RN [1] {ECO:0000313|EMBL:CCZ12815.1, ECO:0000313|Proteomes:UP000017987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:1092 {ECO:0000313|Proteomes:UP000017987};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|RuleBase:RU000675};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ12815.1}.
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DR EMBL; CAZL010000383; CCZ12815.1; -; Genomic_DNA.
DR AlphaFoldDB; R5P8L2; -.
DR STRING; 1262919.BN465_02047; -.
DR Proteomes; UP000017987; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 3.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF165; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU000675};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000675};
KW Reference proteome {ECO:0000313|Proteomes:UP000017987};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..787
FT /note="Beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004388388"
FT DOMAIN 695..787
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
SQ SEQUENCE 787 AA; 87797 MW; B78BD6374524C564 CRC64;
MRLTKLFTTL ALAATMAMAP SAADAAPKAG DFTVGKGTFL LNGNPFVVKA AEVHYPRIPQ
AYWDHRIKMC KALGMNTVCI YVFWNIHEQK EGQFDFTGNN DVAAFCRLAQ KNGMYVIVRP
GPYVCAEWEM GGLPWWLLKK KDIRLREQDP YFMQRVKIFE EKVAEQLAPL TIQNGGPIIM
VQVENEYGSY GEDKAYVSEI RDVLKANWYK KNADGKLVGP ALFQCDWASN FTKNGLDDLV
WTMNFGTGAN IDSQFRRLGE LRPDAPKMCS EFWSGWFDKW GARHETRPAK DMVEGIDEML
SKGISFSLYM THGGTSFGHW AGANSPGFAP DVTSYDYDAP INEWGLATPK FFELRKMMAK
YNDGKKMPAI PKAPMSIVTV PKFQLSEFAS IAFGVDSITK SGLKTFEEMD MGWGSMLYRC
VLPEIPSAST LSANIHDFGQ VFLNGKYIGK VDRVKNEKTV NLPAVKKGDE LMILVEGMGR
INFGRAIKDF KGIVGDVTIT TEYGNNEYTI KPKTWASCTI PDDYQTAIHA LNRAKQAKST
RVIGKAGYYR GYFNLKKVGD TFLDFETWCK GQVYVNGHAM GRIWSIGPQQ TLYVPGCWLK
KGRNEVVVLD VVGPRNAVVW GQAKPELNKL QLEKSNKHNN IGDKPDLNSM TPAAKGAFNS
GNGWQTVKFG QSAKGRYLAI ECSSLHDGSD IAAIAELYVQ GANGKRLSRE SWTTKYADSE
EENGNHTGDK VFDLQESTYW KTVKGSGFPH LLVIDLGSVQ TISALEYLPR AEQGAPGSIK
DYKIFVF
//
