ID   R5PW22_9BACT            Unreviewed;       603 AA.
AC   R5PW22;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   SubName: Full=DNA mismatch repair protein MutS {ECO:0000313|EMBL:CCZ13107.1};
GN   ORFNames=BN465_02326 {ECO:0000313|EMBL:CCZ13107.1};
OS   Prevotella sp. CAG:1092.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1262919 {ECO:0000313|EMBL:CCZ13107.1, ECO:0000313|Proteomes:UP000017987};
RN   [1] {ECO:0000313|EMBL:CCZ13107.1, ECO:0000313|Proteomes:UP000017987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:1092 {ECO:0000313|Proteomes:UP000017987};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ13107.1}.
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DR   EMBL; CAZL010000424; CCZ13107.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5PW22; -.
DR   STRING; 1262919.BN465_02326; -.
DR   Proteomes; UP000017987; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   PANTHER; PTHR11361:SF99; DNA MISMATCH REPAIR PROTEIN-RELATED; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017987};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          429..603
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|SMART:SM00534"
SQ   SEQUENCE   603 AA;  67537 MW;  3DD07363826DDB3D CRC64;
     MIRTKSEILK GYEAKASEIS QEINKTKSRG RLLLFAQLTT FVIVIMSVVA YTLWHEGMVC
     GIVAAISVLA YLLSRYADGK NSERADHLKA LQHTYMGEMA YLDGNFSAFY DGERYLNPHH
     EFSFDLDIFG PQSLFHRINR SITRGGSDRL AECCSLSNKT TISDIANERE AINEMAELSD
     LRMEFMALTD GEVLETNKVY DALDDVKTLQ LPKFATSGSA KWLAMASVGI MAALTCWSAF
     GSLPSNVPLL WGLMQTIVCL TLCGKHISEA NKVVGEIERQ TKGYAKIMRL IASHEYSAKL
     NKDVAEILSS SDANALQALK ELTAIIDAID RRGHALYMVL ADALVLNDLW LVRRFAKWKQ
     KYQDEASAWI DAVSIFDTRV SMATFRYNEP RGIDATIVDE DKVVYDAKDL YHPFLGDKAV
     ANDFNIQDGN YYIVTGANMA GKSTFLRSVG INYILALCGM PVFASNYRVS LFSLFSSMRT
     SDDLAHGISY FNAELLRLKQ LIDTCRENSR TLIILDEILK GTNSADKLNG SRMFLEAMSK
     MPVTGIIATH DLELSKMAEQ YPQRFHNYCF EIELGTSVTY SYKITPGVAR NQNATFLLKE
     ILK
//