ID R5QDP0_9FIRM Unreviewed; 1975 AA.
AC R5QDP0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=BNR/Asp-box repeat protein {ECO:0000313|EMBL:CCZ26820.1};
GN ORFNames=BN734_00721 {ECO:0000313|EMBL:CCZ26820.1};
OS [Ruminococcus] torques CAG:61.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Mediterraneibacter.
OX NCBI_TaxID=1263108 {ECO:0000313|EMBL:CCZ26820.1, ECO:0000313|Proteomes:UP000017998};
RN [1] {ECO:0000313|EMBL:CCZ26820.1, ECO:0000313|Proteomes:UP000017998}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:61 {ECO:0000313|Proteomes:UP000017998};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC {ECO:0000256|ARBA:ARBA00009348}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ26820.1}.
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DR EMBL; CAZS010000140; CCZ26820.1; -; Genomic_DNA.
DR RefSeq; WP_004845335.1; NZ_HF995127.1.
DR Proteomes; UP000017998; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd00110; LamG; 1.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 1.20.1270.90; AF1782-like; 2.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 2.
DR InterPro; IPR044060; Bacterial_rp_domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR004124; Glyco_hydro_33_N.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR023364; Trans_sialidase_dom3.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR Pfam; PF13088; BNR_2; 1.
DR Pfam; PF07554; FIVAR; 2.
DR Pfam; PF18998; Flg_new_2; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR Pfam; PF02973; Sialidase; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF52266; SGNH hydrolase; 2.
DR SUPFAM; SSF50939; Sialidases; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017998};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1951..1970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..254
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1890..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1750..1777
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1906..1938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1975 AA; 218627 MW; 99108BB0FDC94465 CRC64;
MRDWKRWTAV LLAGSLAFTA ADDMKLIVQA YEMQNEQGQE SYQAESKSKL DDLKEKAVLF
QEFQGEEQRF DGTRAVDVSD HAEQIHKIET GSVVFRFKAS KKADGVLLGA KDKTIDLPTD
LNRGSDCTSF FIRANEKFRM VYKHTAAEHV GPASFSDGNW HTVVVSSQNE KSMRLTIDGQ
EMWSNTDAGN RGLFSKQSVL DQVTIGAQKT KDGQVYKGFQ GEISHVIITS ETLTDADAIA
ISKPETSGEI ASGSAVGEMF QIQYGDNSWV FTGGEAVQGG FAQTRGVRNY VGQFEEYVRW
TKAGNENGRQ RYTINTGKAG QTLKDVVDNY QTLVADYSPK AAAYLVGKED YQAGEAGIAS
FQDSLRQFIN LSLGLKENGK GFAVIQKPFA VKDDAVNATI MLYCKAVDEV VKEYEDESEK
LDRIVVVDHF AQTNQDDFKN NKLKDGQTLN AAGHFEIGKQ FSAATIKTTD SYPGNGVTLN
LKEEEQPDVY LNVLPVVTAE NAGLHVQIPE TNETSWRYEL SIGDKKITGS ADGNTFTITG
AESGKEYLFK CISSDGTTQL QTVTGKTEAG NVGIAYGQTL DEKQKALSEK LKEKDKMTWL
FMGDSITHAA LWTKGYDGIA QTFEKYLKDE MGRASDTVIN TAVSGATTTS TLNNIEQRLE
KYTPDVVSIM LGTNDAATGG LTADIYKKNL ETIIEKIRNK NKDAVIILRT PTPMWNTGSR
EANIPQYIAK MKQVADEQNL IYIDQYTELQ KAFNDYGWLK KDTVLFGNNL HPGANGHLLM
TRHFLKGCGL WKEDSAIANL FYEMPINEKT SEITPEVIKT PNRIGVSLEK LKEDSKSQIG
AVHLKAVSKA SGQTYETDAE AGEKLIVLKN LPENQKYEVE VSAWLKDRAE KTVFQKQEIE
LNNTLEEAFD ICLSDEKVEN LNEGTTVGTF TVNEMAPEGN YVFSLCTGEG DTHNPYFAIE
NGVLKTAKKL EEGKTYTIRL KAKNAEAEKE KIFKIYAVGR GLVFRKEDQK IAVGSPVELS
TKDYAEKLMK LEEGTILVHY TSTSDQAIQS LFSVSNAKAG HENRHFHVYI RPEGVLGCEI
RNESAMNYGF KAANAVKADY KGKPAENIIA LQADKEKGTY QLFANGEKVL TVDAAALGGY
RFISEITGLD TVSLGATKRG GINKYTFGGN IHKIEVYETP LTDEELIEET KKTAYPELQQ
IFHKNDGTGA NYYRIPALLT LKSGTVISAA DARFGGTHDS PNNIDIAVAR SEDGGKNWSK
PELPFHYEDY EDNTLEIPVG TQTRVNQSAS FIDPVLLQDE ETERVFLISD AMAAGYGSPQ
AVTGSGYKEI QGKKYLKLQK AGETDYNYTV RENGVIYNDT TNQPTEYSLN SNFEILKDNV
LQTVKQKSSR FDPTNGSGQL VTDETDKDVP MNIMYADAVF KALPTTWLYM KYSDDDGKTW
SDPILLNGMV KAEDSRVLVT GPGRGMQIKN GEYKGRLIVP VYDTAQSGII YSDDHGATWN
YAKGPSTKKA AMSESQIVEM PDGTLRVYAR STGSKIAEAV SLDGGKTWTE AAYVPGMTQP
GWGSQLSVIR YGGLIEGKPA LIMSTPAGVG NYRRDGRVKI GLITDTGKEG SEKYKIDWTY
DYSVDSKNAG FAYSCLSELP NHQIGLMYEK YDSYNPAELH SQDIMKYEEL SLSELMGKEV
VEIIPQTEGK GTVSQRNTVK KGSKITIEAY PEEGYQFVRW EDEKGNPVSE QEKYTFDAKE
SAAFTAVFEQ EKEEVDKSHL KEAIRHAEEQ MQDEKYQDVI PVVREEYEEA YKNAKAIDEK
PDATSEEVET AYKTLIEVGK RLTMYKGDLT ELQAAYDLYA GKDLSIYTQD SKTVLEEALK
EAEKVLKLGE NAVKEDVNEA LEKLQKAIEG LEKSEPNPPT DPEFPTDPDS GNTDIVNPDN
SLSPDDTPST NGTPSASDEK AVATGDKETP VGWTTLGFAA MLAAAGRFLG RKKRR
//
