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Database: UniProt
Entry: R5SNW4_9CLOT
LinkDB: R5SNW4_9CLOT
Original site: R5SNW4_9CLOT 
ID   R5SNW4_9CLOT            Unreviewed;        73 AA.
AC   R5SNW4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Translational regulator CsrA {ECO:0000256|HAMAP-Rule:MF_00167};
GN   Name=csrA {ECO:0000256|HAMAP-Rule:MF_00167};
GN   ORFNames=BN771_01224 {ECO:0000313|EMBL:CCZ52529.1};
OS   Clostridium sp. CAG:75.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262836 {ECO:0000313|EMBL:CCZ52529.1, ECO:0000313|Proteomes:UP000018032};
RN   [1] {ECO:0000313|EMBL:CCZ52529.1, ECO:0000313|Proteomes:UP000018032}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:75 {ECO:0000313|Proteomes:UP000018032};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: A translational regulator that binds mRNA to regulate
CC       translation initiation and/or mRNA stability. Usually binds in the 5'-
CC       UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding,
CC       thus repressing translation. Its main target seems to be the major
CC       flagellin gene, while its function is anatagonized by FliW.
CC       {ECO:0000256|HAMAP-Rule:MF_00167}.
CC   -!- SUBUNIT: Homodimer; the beta-strands of each monomer intercalate to
CC       form a hydrophobic core, while the alpha-helices form wings that extend
CC       away from the core. {ECO:0000256|HAMAP-Rule:MF_00167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00167}.
CC   -!- SIMILARITY: Belongs to the CsrA/RsmA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00167}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ52529.1}.
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DR   EMBL; CBAE010000194; CCZ52529.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5SNW4; -.
DR   Proteomes; UP000018032; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0048027; F:mRNA 5'-UTR binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0044781; P:bacterial-type flagellum organization; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:1902208; P:regulation of bacterial-type flagellum assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0006109; P:regulation of carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.40.4380; Translational regulator CsrA; 1.
DR   HAMAP; MF_00167; CsrA; 1.
DR   InterPro; IPR003751; CsrA.
DR   InterPro; IPR036107; CsrA_sf.
DR   NCBIfam; TIGR00202; csrA; 1.
DR   PANTHER; PTHR34984; CARBON STORAGE REGULATOR; 1.
DR   PANTHER; PTHR34984:SF1; CARBON STORAGE REGULATOR; 1.
DR   Pfam; PF02599; CsrA; 1.
DR   SUPFAM; SSF117130; CsrA-like; 1.
PE   3: Inferred from homology;
KW   Bacterial flagellum biogenesis {ECO:0000256|ARBA:ARBA00022795,
KW   ECO:0000256|HAMAP-Rule:MF_00167};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00167};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018032};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_00167};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00167};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845, ECO:0000256|HAMAP-
KW   Rule:MF_00167}.
SQ   SEQUENCE   73 AA;  8140 MW;  E87A021C94480B81 CRC64;
     MLALARKVNE SIMIGNDIEI TVLEIKGDQI KLGVKAPKSV PIYRKELYVQ IQEENKQAGS
     AVDVEALRGL FQK
//
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