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Database: UniProt
Entry: R5U546_9BACE
LinkDB: R5U546_9BACE
Original site: R5U546_9BACE 
ID   R5U546_9BACE            Unreviewed;       813 AA.
AC   R5U546;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   08-MAY-2019, entry version 26.
DE   SubName: Full=Homoserine dehydrogenase {ECO:0000313|EMBL:CCZ73135.1};
GN   ORFNames=BN535_02828 {ECO:0000313|EMBL:CCZ73135.1};
OS   Bacteroides caccae CAG:21.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides; environmental samples.
OX   NCBI_TaxID=1263037 {ECO:0000313|EMBL:CCZ73135.1, ECO:0000313|Proteomes:UP000017990};
RN   [1] {ECO:0000313|EMBL:CCZ73135.1, ECO:0000313|Proteomes:UP000017990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:21 {ECO:0000313|Proteomes:UP000017990};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCZ73135.1}.
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DR   EMBL; CBAN010000094; CCZ73135.1; -; Genomic_DNA.
DR   Proteomes; UP000017990; Unassembled WGS sequence.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:InterPro.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009067; P:aspartate family amino acid biosynthetic process; IEA:InterPro.
DR   CDD; cd04257; AAK_AK-HSDH; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041743; AK-HSDH_N.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR011147; Bifunc_aspartokin/hSer_DH.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF13840; ACT_7; 2.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000727; ThrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 2.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000017990}.
FT   DOMAIN      317    391       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   DOMAIN      398    471       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   813 AA;  88846 MW;  6B703B500D275B14 CRC64;
     MKVMKFGGTS VGSVNSILSV KRIVESASAG EPVIVVVSAL GGITDKLINT SKMAATGDSA
     YEGEFREIVY RHVEMIKEVV PAGEGQVALQ RQIGELLNEL KDIFQGIYLI KDLSPKTSDT
     IVSYGERLSS IIVAELIKDA KWFDSRTFIK TEKKHNKHTI DADLTNKLVK ETFSSIPKVA
     LVPGFISSDK TTGEVTNLGR GGSDYTAAII AAALNADSLE IWTDVDGFMT ADPRVISTAY
     TISELSYVEA TELCNFGAKV VYPPTIYPVY HKNIPIIIKN TFNPDGVGTV IKQEVSNPHS
     KAIKGISSIN DTSLITVQGL GMVGVIGVNY RIFKALAKNG ISVFLVSQAS SENSTSIGVR
     NADADLACEV LNEEFAKEIE MGEISPILAE RNLATVAIVG ENMKHTPGIA GKLFGTLGRN
     GINVIACAQG ASETNISFVV DAKSLRKSLN VIHDSFFLSE YQVLNLFICG IGTVGGSLVE
     QIRCQQEKLM LENGLKLHVV GIIDATKAMF SREGFDLANF REELQQKGKD SNLQTIRDEI
     VGMNIFNSVF VDCTASPDIA SLYKDLLQHN ISVVAANKIA ASSAYENYRE LKTIARQRGV
     KYLFETNVGA GLPIINTIND LIHSGDKILK IEAVLSGTLN YIFNKISADI PFSRTIKMAQ
     EERYSEPDPR IDLSGKDVIR KLVILAREAG YRIEQEDVEK NLFVPNDFFE GSLDDFWKRV
     PSLDADFEAR RQVLEKEHKH WRFVAKLEDG KASVGLQEVG ANHPFYGLEG SNNIILLTTE
     RYKEYPMMIQ GYGAGAGVTA AGVFADIMSI ANV
//
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