ID   R5UB36_9FIRM            Unreviewed;       554 AA.
AC   R5UB36;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Uridine kinase {ECO:0000313|EMBL:CCZ66157.1};
GN   ORFNames=BN683_00788 {ECO:0000313|EMBL:CCZ66157.1};
OS   Roseburia sp. CAG:50.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262949 {ECO:0000313|EMBL:CCZ66157.1, ECO:0000313|Proteomes:UP000018378};
RN   [1] {ECO:0000313|EMBL:CCZ66157.1, ECO:0000313|Proteomes:UP000018378}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:50 {ECO:0000313|Proteomes:UP000018378};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ66157.1}.
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DR   EMBL; CBAK010000282; CCZ66157.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5UB36; -.
DR   Proteomes; UP000018378; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02028; UMPK_like; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR006083; PRK/URK.
DR   InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR   PANTHER; PTHR10285:SF159; PHOSPHORIBULOKINASE _ URIDINE KINASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR10285; URIDINE KINASE; 1.
DR   Pfam; PF00485; PRK; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:CCZ66157.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018378};
KW   Transferase {ECO:0000313|EMBL:CCZ66157.1}.
FT   DOMAIN          293..489
FT                   /note="Phosphoribulokinase/uridine kinase"
FT                   /evidence="ECO:0000259|Pfam:PF00485"
SQ   SEQUENCE   554 AA;  64133 MW;  94C54053BE74A288 CRC64;
     MKQQMCKITI QGTEREYPRE TTFQQIADEY QSQMENDIVL VKFQQDLREL HQSVLRDGEL
     EFITTAEKPG RDTYRRSVTL LMEAAAWKLY PNLELLVQHS IGQGYYCEFR HADAICVPDQ
     KMLQALKEKM QAFVEADLPI VKYNMSTQDA SARFRQMGRM DKVRLMRYRR SSRVNVYELQ
     EFPDYYYGYM VPGTGYLKYF DLLPYQNGFM LMFPGKETRK VADFEVTDKL FNTLNDSAQW
     GIDMGIRTVG ELNDVIAAGR IQDMILVQES YMEQKIGDIA ETIAADRRKK FVLIAGPSSS
     GKTTFSHRLS IQMTAHGLKP HPISLDDFYC NREETPLDEN GEYDFECLEA LDIPLFNQCM
     TDLLAGKEVI LPVFNFKTGH REYRQKPLKL GAEDVLVIEG IHGLNEKLSY ELPKENKYKI
     YISALTQLNI DDHNNLSTAD GRLIRRMVRD ARTRNTSARE TLARWNSVRR GEEKNIFPYQ
     EEADVMFNSA LIYELSVLKL YAEPLLFSID ADCPEYPEAK RLLKFLDYFL PVPGENIGHN
     SILREFIGGS CFHV
//