ID R5USL2_9FIRM Unreviewed; 900 AA.
AC R5USL2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Translation elongation factor G {ECO:0000313|EMBL:CCZ78719.1};
GN ORFNames=BN518_02245 {ECO:0000313|EMBL:CCZ78719.1};
OS Roseburia sp. CAG:18.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262941 {ECO:0000313|EMBL:CCZ78719.1, ECO:0000313|Proteomes:UP000018230};
RN [1] {ECO:0000313|EMBL:CCZ78719.1, ECO:0000313|Proteomes:UP000018230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:18 {ECO:0000313|Proteomes:UP000018230};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ78719.1}.
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DR EMBL; CBAP010000116; CCZ78719.1; -; Genomic_DNA.
DR AlphaFoldDB; R5USL2; -.
DR Proteomes; UP000018230; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd10912; PIN_YacP-like; 1.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR010298; YacP-like.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF05991; NYN_YacP; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Elongation factor {ECO:0000313|EMBL:CCZ78719.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000018230}.
FT DOMAIN 7..243
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 665..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 100906 MW; 6AC6934882ADEB94 CRC64;
MSRKNPAKNI NIGLLAHVDA GKTTLSEALL YATGQIRALG RVDHQDAFLD TDAQERARGI
TIFSKQARFR LQMTDENLHS ESSVGITILD TPGHVDFSAE MERTLQVLDY AILVISGTDG
VQGHTRTLWR LLRHYHIPTF LFVNKMDLPG ADKEAVQQQL KTELSDGCVD FTQDSGEAFF
EEAAMGSEAL LDEYMEQGSI AEEHLAHAVA NRDLFPCYYG SALKVEGVKE LLAGFAKYHR
APEYEDEFSA RVYKIGRDTK GARLTYLKVT GGTLHVKDRI SYDGLEEKVD QIRLYSGEKF
ETAEAVEAGE VCAVTGLTTT VPGQGLGAQQ ESSVPVLEPV LNYRIYLPDE VNAVEMMEKL
KQLEEEDPQL HILWNEQLQE IHAQMMGQVQ IEVLTQLIKE RFGVVVVFGQ GNIVYKETIA
KPVEGVGHFE PLRHYAEVHL LLEPGEPGSG IEVASACSED VLDLNWQRLI ATHIMEREHP
GVLTGSALTD VKITILSGRA HIKHTEGGDF RQATYRAIRQ GLKSTESVLL EPVYAFTLEV
PQEMVGRAMT DLKQRAGKFD SPEFGTGNGM DYAVLQGTVP VATMQDYSSE VHAYTRGLGH
LTLELSGYDV CHNSEEVIAG IGYDSEADTA NPTGSVFCAH GAGFIVPWDQ VDDYMHLPQQ
FVPEEETQTP TDGRSYETDG QSFGPVHRQQ SSGKTGWELD QELQQIYARE FGMSREDMED
QERRKWLKKK SDAPKPNVVK YDKKGNPIYP AKEPQEEYLI VDGYNIIFAW KDLNELSRVN
IDSARDKLLD ILSNYQGYKS CPVLVVFDAY KRKEHPGAKS KYHNLDVVYT KTDETADAFI
ERTVHEIGHK YRVTVATNDG LEQLTVMSQG ALRMSADNLR EEIERLSRLE YENYLASQKR
//
