ID R5VKB2_9CLOT Unreviewed; 398 AA.
AC R5VKB2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Cysteine desulfurase NifS {ECO:0000313|EMBL:CCZ91133.1};
GN ORFNames=BN512_01835 {ECO:0000313|EMBL:CCZ91133.1};
OS Clostridium sp. CAG:167.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262777 {ECO:0000313|EMBL:CCZ91133.1, ECO:0000313|Proteomes:UP000018023};
RN [1] {ECO:0000313|EMBL:CCZ91133.1, ECO:0000313|Proteomes:UP000018023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:167 {ECO:0000313|Proteomes:UP000018023};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU004504};
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. NifS/IscS subfamily.
CC {ECO:0000256|ARBA:ARBA00006490}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ91133.1}.
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DR EMBL; CBAV010000139; CCZ91133.1; -; Genomic_DNA.
DR AlphaFoldDB; R5VKB2; -.
DR STRING; 1262777.BN512_01835; -.
DR Proteomes; UP000018023; Unassembled WGS sequence.
DR GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.260.50; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR020578; Aminotrans_V_PyrdxlP_BS.
DR InterPro; IPR016454; Cysteine_dSase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR Pfam; PF00266; Aminotran_5; 1.
DR PIRSF; PIRSF005572; NifS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000018023}.
FT DOMAIN 4..365
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
SQ SEQUENCE 398 AA; 44035 MW; D9DFA3348629D9BC CRC64;
MTEVYLDHAA TTKLSKEALG AMLPYLLNEY GNPSSQYSIG ERARKAVTKA REQIAAALWC
SPEEIYFTSG GTEADNWAFE LAVSDERTGQ ILVSQIEHPA VRKKAETYEK AGLRVERIPV
DENGIIILSA LEKMVGPDTR LVSVMTVNNE IGTIQPIQQI GTLLHQKSPQ TLFHTDAVQA
YGHMQLDPHR SYVHLLSASA HKFGGPKGTG FLYIEKSVKQ RSLLKGGGQE RGMRAGTENV
AGIVGMAAAS RQAYENLDMR SAYVQSLRDY LIERIENEIP FVRLNGSRIN RLYNNVNISF
SYVQGKNLVA MLDMNGICCS GGAACSANKS EPSPVLMALG IPKKIAQGGL RITLGEDNTK
EEMDYTVYCI KKAVQQLREN NPLYSRFSEY NLHHWSNG
//
