ID R5VM31_9CLOT Unreviewed; 1137 AA.
AC R5VM31;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN512_00609 {ECO:0000313|EMBL:CCZ91808.1};
OS Clostridium sp. CAG:167.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262777 {ECO:0000313|EMBL:CCZ91808.1, ECO:0000313|Proteomes:UP000018023};
RN [1] {ECO:0000313|EMBL:CCZ91808.1, ECO:0000313|Proteomes:UP000018023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:167 {ECO:0000313|Proteomes:UP000018023};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ91808.1}.
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DR EMBL; CBAV010000220; CCZ91808.1; -; Genomic_DNA.
DR AlphaFoldDB; R5VM31; -.
DR STRING; 1262777.BN512_00609; -.
DR Proteomes; UP000018023; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR049035; ADDB_N.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR Pfam; PF21445; ADDB_N; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018023}.
FT DOMAIN 276..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 1137 AA; 131768 MW; A672DDD4E6A74353 CRC64;
MSLQFITGAC GSGKSTYLCR SICQEAKKHI DKNYIILVPD QFTLETQKNM VEFSGGQGIL
NIDVLSFHRL AYRVLEEMPV HRRTVLEDMG KMMLLRKVFA EEKKNLVYFK RGLNKPGFLD
ECKSFFCELM QYAITEEDFS DLFGQFEKES LMSYKMQDLQ LIYRRFMEKM GDSYMMAEEL
IPQLTALVPQ VGFLKDAVIC LDGFTGFTPT QYDLLKVLMK AGSQMYVTVT TDRTGRRRGV
FSLSQQVMKK MAKLAEETGT EIQPVVTLGR GEEKAPFRQE EGSELAFLEK NIFAHRYETW
KEAPEDIEIR VCKRGQDEAA FAARTIDRLV ETEGYQYEDI AVVVGQIKDY EQALAREFHR
LNIPFFMDYK KSMGANALAE YVLALLGMYK KNMDYDSTFR FLRCGLSPLT TEETDHLDNY
VVAKGKKGYR SYAQEWKSPL RYSDLVAVNE AKDKFVASIK EFFQALRGGK KTVREFSGIL
YRHLVENHIY QRVNGLAEEF EKMEQALLAR EYHRIYRLFM ELLDEMVDLL GDETVTFSEY
EEILKAGVSE GLVGFTPPEK NQVKIGDRER SRLGDVKVLF FIGVTDDVIP KGAQSPGILS
QTEREKLEQM GVELAPQGEE AASMEQYYLY LTLAKPSQKL YLTYCKLGND GSSRRPAYLI
NKILGLFETL KVRDEEKEEP ETWQILGSDT GKGYLLTKLA AGDYEKDDRF WELAAFYARE
ESEWWKTMID RGTPKYEKGR ISKAVAEQLY TDKLFGSVTR FEQYAKCPFA HFALYGLGVR
EREEFAVNAM DYGNVFHKAL EHVSHRMEKE KKDWNSLSLD EIREMAKEAI DTVSQEYEEG
KYFQNHRTKY CVTRMKRVLQ QSMEGIWHQM QQGEFFQYFS EKKFPDKDKM ESTHLDLGGG
REIVLHGQID RVDVCYRKDK QLIKIVDYKS SDQQLNLGKV YYGLQIQLLS YMAAAMEIMD
QESGQQAEPA AMLYYTVKKP QIPWKPETDK QRRERILKEL RCQGYVNEEP YILEALDESL
SDGEELTPMA SSQVVPVRIK RDRNFYSDSK VLSTEQFEIL MEHTKKKLMQ YGKEIYEGAC
GRTPYEMKQE NGCMYCHLKG VCGMDGSRGN DLEVRKLDEL KEDEVWRLLD GSDKLDE
//
