ID   R5WYE0_9FIRM            Unreviewed;       827 AA.
AC   R5WYE0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Anaerobic ribonucleoside-triphosphate reductase {ECO:0000313|EMBL:CDA05004.1};
GN   ORFNames=BN568_01549 {ECO:0000313|EMBL:CDA05004.1};
OS   Blautia sp. CAG:257.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=1262756 {ECO:0000313|EMBL:CDA05004.1, ECO:0000313|Proteomes:UP000018056};
RN   [1] {ECO:0000313|EMBL:CDA05004.1, ECO:0000313|Proteomes:UP000018056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:257 {ECO:0000313|Proteomes:UP000018056};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA05004.1}.
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DR   EMBL; CBBB010000056; CDA05004.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5WYE0; -.
DR   STRING; 1262756.BN568_01549; -.
DR   Proteomes; UP000018056; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008998; F:ribonucleoside-triphosphate reductase activity; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd01675; RNR_III; 1.
DR   CDD; cd02947; TRX_family; 1.
DR   Gene3D; 3.20.70.20; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR012833; NrdD.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   NCBIfam; TIGR02487; NrdD; 1.
DR   PANTHER; PTHR21075; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR21075:SF0; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF13597; NRDD; 1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00492};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00492}; Reference proteome {ECO:0000313|Proteomes:UP000018056}.
FT   DOMAIN          40..133
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000259|PROSITE:PS51161"
SQ   SEQUENCE   827 AA;  94453 MW;  209514A9B21D5160 CRC64;
     MIAQYMVVFA VDGTCDLCYN VIYQQKIRAS KAREEEGLMF QVVKRDGEIA EFQMAKISSA
     ISRAFDAKEK NYSKDMIDLL SLRVTADFQD KIQDDRVTVE DIQDSVENVL IQAGYSDVAK
     AYILYRKQRE KIRNMKSTIL DYKEIVNSYV KVEDWRVKEN STVTYSVGGL ILSNSGAVTA
     NYWLSEIYDN EIADAHRNAD IHIHDLSMLT GYCAGWSLKQ LIQEGLGGIE GKITSAPAKH
     LSVLCNQMVN FLGIMQNEWA GAQAFSSFDT YLAPFVKADK LSYREVKKCI ESFIYGVNTP
     SRWGTQAPFS NITLDWTVPD DLAELPAIVG GKEMDFKYKD CKKEMDMVNR AFIETMIEGD
     ANGRGFQYPI PTYSITKDFD WSDTLNNQLL FEMTAKYGTP YFSNYINSDM KPSDIRSMCC
     RLRLDLRELR KKSGGFFGSG ESTGSVGVVT INMPRIAYQS RNPEEFYRRL DHMMDIAARS
     LHIKRQVISR LLNEGLYPYT KRYLGSFDNH FSTIGLVGMN EAGLNARWLG CDMTDERTQK
     FTKEVLEHMR NRLSDYQEQY QGELFNLEAT PAESTAYRLA KHDRKRWPDI KTAGKEGDTP
     YYTNSSHLPV EFSSDIFDAL DIQDELQTLY TSGTVFHGFL GEKLPDWKAA ASLVRKIAEN
     YKLPYYTISP TYSVCSEHGY LSGEHFTCPK CGKKAEVYSR ITGYYRPVQN WNDGKAQEYK
     NRTLYDVVHS SLKKVHTSVV TMTEDDVKVQ PVETHKYLFT TSTCPNCRMA KKMLEGEELE
     IIDAEKNPDM ARQFGIMQAP TLVITDGEHL KKYVNASNIQ KYVDEEL
//