ID   R5XBL4_9FIRM            Unreviewed;      1108 AA.
AC   R5XBL4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=ATP-dependent nuclease subunit B {ECO:0000313|EMBL:CDA05801.1};
GN   ORFNames=BN568_02150 {ECO:0000313|EMBL:CDA05801.1};
OS   Blautia sp. CAG:257.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=1262756 {ECO:0000313|EMBL:CDA05801.1, ECO:0000313|Proteomes:UP000018056};
RN   [1] {ECO:0000313|EMBL:CDA05801.1, ECO:0000313|Proteomes:UP000018056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:257 {ECO:0000313|Proteomes:UP000018056};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA05801.1}.
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DR   EMBL; CBBB010000165; CDA05801.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5XBL4; -.
DR   STRING; 1262756.BN568_02150; -.
DR   Proteomes; UP000018056; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR049035; ADDB_N.
DR   InterPro; IPR014140; DNA_helicase_suAddB.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   NCBIfam; TIGR02773; addB_Gpos; 1.
DR   PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR   PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR   Pfam; PF21445; ADDB_N; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018056}.
FT   DOMAIN          5..288
FT                   /note="ATP-dependent helicase/deoxyribonuclease subunit B
FT                   N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21445"
FT   DOMAIN          762..1077
FT                   /note="PD-(D/E)XK endonuclease-like"
FT                   /evidence="ECO:0000259|Pfam:PF12705"
SQ   SEQUENCE   1108 AA;  128347 MW;  D23D806381517AC2 CRC64;
     MPLQFIIGNS GSGKSYTVFQ SVIQEAREHP EQLFYVIVPE QFTMQTQKTL VEMHPDGGIL
     NIDVLSFERL AFRVFEEVGG DTRKILEETG KNMVLQKLVQ KHQKDLVYLK NQMKKPGYLD
     EVKSLISEFM QYEVGEQELE RMKEDASDRA LLQMKLQDVT VLYQAFRDYL REHYMTPEEV
     LEVLAKEIVF SEKLRGSVLV LDGFTGFTPV QMKVVKELLA VCSKVLVTVT MDVQEPFMGK
     EKSHQLFYMS HKMIRGLCEL TKETEEPVWI KAGEKSRFAH SPALSFMEKN LFRYRRQVYK
     QEQKEISIFS AGTPLKEMEE TARRILRLVR KEGYRFGEIA VITGNLEEYG NLARQAFDNS
     GIPCFIDEKH SILMNPFVEY VRAALEMAAQ GFSYESVFRY LRCGMSDITR QETDWLENYV
     VALGIRGFKK WKEKWVRIYR GMKEESILEL NEIRERFVRE TEELARGFSG KKKTVKEYCG
     FLYEFIVRSR IQEKLYEQEE VFCRKGDRAM EKEYAQIYGI VMELLDKMTE ILGEETVSPE
     EFRQILETGM SQAKVALIPP GLDQVLVGDM ERTRLKDARA LFFVGVNEGN IPKNTESGGI
     LTELDREFFA DQGVELAPGP KELMNIQRFY LYLNLTKPSE HLCLSFANSN MKGEAVSPAY
     LIHTVRRLYP QLHPERAEEP ESFLELLETP STGMDYFLEI LGSHTDKYEE PLFQELYSWY
     LRSPEYQELT KKLTDAAFMR KPADRISASV ARALYGEVSP NSATRLERFA ACAFAHFLRY
     GLEITERAEY EFRAMDMGNV IHQALEKFAA ELQRKGLRWS ELDEEERNSI VEECLNQVAA
     DYGNTILKSS ARNQYMIERT SRILKRTVWA LQEQLRQGEF LPEGFEVSIG GGRIDRLDVL
     KEDKKVYVKI IDYKSGNTSF DLVSLYHGLQ LQLVVYMDAA LDAEQRKHPD CDIQPAGIFY
     YNVKDPMIQE NIQADMDSIQ PGLLKELKMN GLVAANSEVI QKMDRSLVSL PVTYNKDGSF
     RKGSSVATRE QFRLLNEYVK RKISDIRGEI LSGDTEISPY ELGKRTACTY CSYQGVCGFD
     RKIPGYEYRR LKQFSDQEIW NHLEEEER
//