ID R5Z234_9MOLU Unreviewed; 459 AA.
AC R5Z234;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2 6-diaminopimelate ligase {ECO:0000313|EMBL:CDA22907.1};
GN ORFNames=BN735_00142 {ECO:0000313|EMBL:CDA22907.1};
OS Mycoplasma sp. CAG:611.
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=1262905 {ECO:0000313|EMBL:CDA22907.1, ECO:0000313|Proteomes:UP000018049};
RN [1] {ECO:0000313|EMBL:CDA22907.1, ECO:0000313|Proteomes:UP000018049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:611 {ECO:0000313|Proteomes:UP000018049};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|RuleBase:RU004135}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004135}.
CC -!- SIMILARITY: Belongs to the MurCDEF family. MurE subfamily.
CC {ECO:0000256|ARBA:ARBA00005898}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA22907.1}.
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DR EMBL; CBBK010000008; CDA22907.1; -; Genomic_DNA.
DR AlphaFoldDB; R5Z234; -.
DR STRING; 1262905.BN735_00142; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000018049; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR Gene3D; 3.40.1390.10; MurE/MurF, N-terminal domain; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR004101; Mur_ligase_C.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR InterPro; IPR035911; MurE/MurF_N.
DR InterPro; IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase.
DR NCBIfam; TIGR01085; murE; 1.
DR PANTHER; PTHR23135; MUR LIGASE FAMILY MEMBER; 1.
DR PANTHER; PTHR23135:SF4; UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE MURE HOMOLOG, CHLOROPLASTIC; 1.
DR Pfam; PF02875; Mur_ligase_C; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
DR SUPFAM; SSF63418; MurE/MurF N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|RuleBase:RU004135};
KW Cell division {ECO:0000256|RuleBase:RU004135};
KW Cell shape {ECO:0000256|RuleBase:RU004135};
KW Cell wall biogenesis/degradation {ECO:0000256|RuleBase:RU004135};
KW Ligase {ECO:0000313|EMBL:CDA22907.1};
KW Peptidoglycan synthesis {ECO:0000256|RuleBase:RU004135};
KW Reference proteome {ECO:0000313|Proteomes:UP000018049}.
FT DOMAIN 85..280
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
FT DOMAIN 301..382
FT /note="Mur ligase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02875"
SQ SEQUENCE 459 AA; 53337 MW; 66C8E76A055C5B61 CRC64;
MLKFKNNSKN IKNGDIFICT HDTYDDRHKY INDAIKNGCK AIIIDKDIKA NNKMFIKVQN
TNDTYYQILN NYYNYPLDNL KLIGITGTDG KTTTAMIIND LLNNYVNSSY LGTNGFILKE
KVIKTKNTTP SIDTLFKYFD VLNKNNYDNL VMEVSSEALL HNRCHNINFD IAVLTNIKKD
HLNVHKTFKN YLESKTKLFK QANLCILNKD DKHFNYIKRK CNKNIITYGT KKKCDYYFYD
INEYNDKTTF KLKVNDKIYN ITSPLIGKFN VYNLVSAIAT LNCFNINITS IINNIKKIKQ
VPGRLQKIDF KQNYDIVLDY AHTSNATYEV LKLFNKIKKG NIITVVGCAG KRYKDKRSEI
GKIVTTYSDK VIFTMDDPRD EKVLDIINDM ISKVKNNNYE IIENREKAIF EALHLAKEND
TILILGKGLD NYMAISDKYV KYSDLNVIKS YFKKLSKEK
//
