ID R5Z522_9FIRM Unreviewed; 436 AA.
AC R5Z522;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=ATPase histidine kinase-DNA gyrase B-and HSP90-like domain protein {ECO:0000313|EMBL:CDA23912.1};
GN ORFNames=BN528_00808 {ECO:0000313|EMBL:CDA23912.1};
OS Roseburia sp. CAG:197.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262943 {ECO:0000313|EMBL:CDA23912.1, ECO:0000313|Proteomes:UP000018336};
RN [1] {ECO:0000313|EMBL:CDA23912.1, ECO:0000313|Proteomes:UP000018336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:197 {ECO:0000313|Proteomes:UP000018336};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA23912.1}.
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DR EMBL; CBBL010000021; CDA23912.1; -; Genomic_DNA.
DR AlphaFoldDB; R5Z522; -.
DR Proteomes; UP000018336; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032834; NatK_C.
DR PANTHER; PTHR40448; TWO-COMPONENT SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR40448:SF1; TWO-COMPONENT SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF14501; HATPase_c_5; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CDA23912.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018336};
KW Transferase {ECO:0000313|EMBL:CDA23912.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 331..433
FT /note="Sensor histidine kinase NatK C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14501"
SQ SEQUENCE 436 AA; 50316 MW; C222B76B1B521C60 CRC64;
MSEGISWFLY IISEFFLYLL AYKVILDAKI EKSFIRWGVC IGGVTVVLVC AVIMAGFSVC
EWLTMFVMVS IPLFLLNKDR RIQYLIMYPF IVMASSLVGV AMSYIFAFMM KTGEYYIIED
RRVAVGCQAI SIVVLLLLWL FRMRRKKCYE IRLEWKQFFL FYIVLLCLLC IVAPIQILAK
HFPNDILITQ VGIASSISAI MLVAVTIWQG ILVNRELIQE REHDEQEQYI INQKQYYEDL
LAQDEKMRRF RHDMNAHFQV LQSYCSDGAN EKMKSYLQKI VISSAIYDKK IITGNTAIDA
VLTPLFEMAA KAKIEISADC LLPEKLEADK EFQICTVISN LFRNAIEACI QIEDPTQRMM
QARIGMYNSQ VVIMISNTIK NEVIIQGKKL VTTKKDSRYH GLGSGNVEHI VQSCNGMIQY
RCENGWFFVD VVMQLE
//
