ID R5ZDS5_9FIRM Unreviewed; 284 AA.
AC R5ZDS5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=BN700_01156 {ECO:0000313|EMBL:CDA34784.1};
OS Firmicutes bacterium CAG:536.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1263028 {ECO:0000313|EMBL:CDA34784.1, ECO:0000313|Proteomes:UP000018332};
RN [1] {ECO:0000313|EMBL:CDA34784.1, ECO:0000313|Proteomes:UP000018332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:536 {ECO:0000313|Proteomes:UP000018332};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01161}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA34784.1}.
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DR EMBL; CBBQ010000097; CDA34784.1; -; Genomic_DNA.
DR AlphaFoldDB; R5ZDS5; -.
DR Proteomes; UP000018332; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07208; Pat_hypo_Ecoli_yjju_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045943; DUF6363.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR037483; YjjU-like.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF25; PHOSPHOESTERASE-RELATED; 1.
DR Pfam; PF19890; DUF6363; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01161};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU01161};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098, ECO:0000256|PROSITE-
KW ProRule:PRU01161}; Reference proteome {ECO:0000313|Proteomes:UP000018332}.
FT DOMAIN 7..172
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT MOTIF 38..42
FT /note="GXSXG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"
FT ACT_SITE 40
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"
FT ACT_SITE 159
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"
SQ SEQUENCE 284 AA; 32466 MW; C0C4B20DF060C75D CRC64;
MFEKMGLVVE GGGTKAAYSA GVLKAFLEEK IYIPYTVGIS AGCEILTSYV ARQIPRLELT
GIQAPCQPGV VGLKPLFKEK SIYGIESTNA FIESREKLDM QAFQSSSSKM DFGLYNMRTH
AVEYYGKEYL DESQTLVKAS CALLLLTHPY MFQGQKYMDA GLVDMISIEQ SIRQGNQKHI
VISTKEVGYV RKPAPNWQLR LAKLVYKDDV IVQDLKKRHE RYNKQWGLVD QLEKDGKALV
LRPHKDLGIT RYTTDPKKLH PWFQLGYDET MERMDQIKEF CEVK
//