ID R5ZXD0_9PROT Unreviewed; 592 AA.
AC R5ZXD0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BN492_01735 {ECO:0000313|EMBL:CDA44148.1};
OS Proteobacteria bacterium CAG:139.
OC Bacteria; Pseudomonadota.
OX NCBI_TaxID=1262986 {ECO:0000313|EMBL:CDA44148.1, ECO:0000313|Proteomes:UP000018405};
RN [1] {ECO:0000313|EMBL:CDA44148.1, ECO:0000313|Proteomes:UP000018405}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:139 {ECO:0000313|Proteomes:UP000018405};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA44148.1}.
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DR EMBL; CBBV010000140; CDA44148.1; -; Genomic_DNA.
DR AlphaFoldDB; R5ZXD0; -.
DR Proteomes; UP000018405; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF12974; Phosphonate-bd; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CDA44148.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018405};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:CDA44148.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..592
FT /note="histidine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004399292"
FT TRANSMEM 307..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 373..585
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 330..364
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 592 AA; 65789 MW; B1DFE1D24995D02C CRC64;
MRWILLILCG LISAYAQASQ LNNLLPPVRL AVVNSFGSNL SVRYFNGTVN AIAKAVAPRR
LVVQFYDQEV FLEAAQNKEF DLAIASSGLT ALMTDASGAA ALLTIINSRT PDPNHANAGV
IVVRSDRDDI NCLADLKGKT VAVSSTKAFA GFLAVMGEIQ AEGLNPNRLF KSVTATHKPM
TELVKQVVNK EVDVAFIASC LLENMEADGV IPKGCLKVIN EKKDENFYCK HSTRLYPGWI
LSAQPTLDSK TLRNIMEALL QLPPGKEEGS YWTVATDYDQ MNLLLQRMEV RYLEDRTIGW
MLNYYRWYFI VGCGALLLII LNWAYLAFAV RRKTEQLRKK VEENREYERE NRKITERIEA
LEKAKSIGII SAMVAHELKQ PLGAINNYSE AILRQLKRGK KPAEEILTEA LSEIKSESQR
ASEIVEFVRN IGRKEPRQRK RFNLESAVEH TIELMKRLGR LNSKCTLTGA ENLFVYADPL
NVDLVLMNLL KNAEEAVRNQ QNAEIKVEIK NAGADALVII EDNGPDMTDD QFASLRNLGQ
SSKKDGLGLG LAIVRELLEA NGGSLKLVRI PSGGLRCIAS LPIALEDKDG PG
//
