ID R6A3W4_9ACTN Unreviewed; 689 AA.
AC R6A3W4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:CDA35832.1};
GN ORFNames=BN511_01090 {ECO:0000313|EMBL:CDA35832.1};
OS Collinsella sp. CAG:166.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae; Collinsella.
OX NCBI_TaxID=1262850 {ECO:0000313|EMBL:CDA35832.1, ECO:0000313|Proteomes:UP000018358};
RN [1] {ECO:0000313|EMBL:CDA35832.1, ECO:0000313|Proteomes:UP000018358}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:166 {ECO:0000313|Proteomes:UP000018358};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA35832.1}.
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DR EMBL; CBBR010000180; CDA35832.1; -; Genomic_DNA.
DR AlphaFoldDB; R6A3W4; -.
DR Proteomes; UP000018358; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..282
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 329..670
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 689 AA; 73600 MW; 54BD641ED30F7AD1 CRC64;
MSSQLTVIIA GIVLVVAIVV ALVIMRRGDS RFTYDTQHGT APRATEGEGN TAATAFKGRF
SILTTGVGAM FAALAVKLWG MQMVSSDYYE KQANSNQTRT VTTPAVRGRI LDRNGVALVQ
NRPSLAVVAY RDLAEDEVLV RHLANVLGMP YVAVLRNIQD NTEGAQSLHT IATDVRRSTV
AYIQEHAGEF PGVKIAERTE RQYPYGETAC HILGYTGTIT SEQLEAQNKK TSGDDDASAG
KITYQSGDIV GQAGVESYYE NLLQGIRGEQ TVKVDASGNV TGQAGAVPAK AGSDIKLTLD
LKIQQACETA LASAIELAKT TGYSNAGNGA VVCLDPNNGE ILGMASQPKF DPSVFIGGVS
NDVWTELNDD KGSHPLLNRA ISGQYMSAST IKPLSALAGL EFGTYTSTQT TNCTGYWTGL
GKAWGKRCWL TSGHGTMTLQ SGIANSCDPV FYDMGKAFFY DEQHSEGLQE VFRRWGLGKT
CGIDLPSEGA GRIPDAEWKE SYFTDASAED RKWNAGDMTN IAIGQGDILV TPLQMACAYM
GLANGGKQYV PHVFLSAVSR DGDGDAYKYN GKGKKKRLEA KINSDSDLAL VRNGMHDVIY
TASTSLAAHF GTLTPQVYGK SGTGEKSGED EYAWFCAYAP ADDPKYVIAT VLEQGGGGSD
TAMHVVRDVL GVIYDEPDTS SASGDSSVR
//
