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Database: UniProt
Entry: R6A4Q7_9PROT
LinkDB: R6A4Q7_9PROT
Original site: R6A4Q7_9PROT 
ID   R6A4Q7_9PROT            Unreviewed;       865 AA.
AC   R6A4Q7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Chaperone protein ClpB {ECO:0000256|ARBA:ARBA00017574, ECO:0000256|RuleBase:RU362034};
GN   Name=clpB {ECO:0000256|RuleBase:RU362034};
GN   ORFNames=BN492_00076 {ECO:0000313|EMBL:CDA43789.1};
OS   Proteobacteria bacterium CAG:139.
OC   Bacteria; Pseudomonadota.
OX   NCBI_TaxID=1262986 {ECO:0000313|EMBL:CDA43789.1, ECO:0000313|Proteomes:UP000018405};
RN   [1] {ECO:0000313|EMBL:CDA43789.1, ECO:0000313|Proteomes:UP000018405}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:139 {ECO:0000313|Proteomes:UP000018405};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE. {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|ARBA:ARBA00026057}.
CC   -!- SUBUNIT: Homohexamer; The oligomerization is ATP-dependent.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362034}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA43789.1}.
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DR   EMBL; CBBV010000113; CDA43789.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6A4Q7; -.
DR   Proteomes; UP000018405; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009408; P:response to heat; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR017730; Chaperonin_ClpB.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03346; chaperone_ClpB; 1.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362034};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362034};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018405};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}; Stress response {ECO:0000256|RuleBase:RU362034}.
FT   DOMAIN          3..146
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   COILED          412..526
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
SQ   SEQUENCE   865 AA;  97421 MW;  141EC565075EF9DD CRC64;
     MRQDQFTTRF QELLGEAQSM AVERSQQYID PLHLLLAVLK DTEGTGRTLL ERSGVRVREL
     ERKVKEAIGK LPEVSGAADN VQISRELMAI LNSMEREAER LGDKFISTDL FLLALCDSKC
     DAARLAQEEG LNKPSLENAI LSVRGGEKVD NPEAENNREA LKKYTVDLTE KAKEGKLDPV
     IGRDDEIRRA MQILQRRSKN NPVLIGEPGV GKTAVVEGLA QRIVNGEVPD TLRNKRVLSL
     DMAGLVAGAK YRGEFEERLK ALLKEVVAEE GRIILFIDEI HTVVGAGKTE GAMDAGNMLK
     PALSRGELHV IGATTLDEYR KYIEKDPALE RRFQKVIVNE PSVEDTIAIL RGLQEKYEVH
     HGVEITDPAI VAAAELSARY ITDRFLPDKA IDLIDEAAAR IKMEIDSKPE ELDKLDRRLI
     QLKIEREAVK KEKDEASKKR LSGLEEEIAK LSREYSDLEE IWKKEKNAAL GSKEVRDEID
     KLKTKMEELR RSGKYEELAA IQYGKLPELE KQLVKEEKEE TKLYDEKPKL LRTQVGAEEI
     AEVVSRATGI PVSKMMEGER QKLLDMAKYI GKRVVGQKEA VDKVVDAILR SRAGLSDPNR
     PYGSFLFLGP TGVGKTELTK ALAEFLFDTE DAMIRIDMSE FMEKHSVARL IGAPPGYVGY
     EEGGYLTEAV RRKPYSVILL DEVEKAHPDV FNILLQALDD GRMTDGQGRT VDFKNTVIIM
     TSNLGSQEIM NRQGEDPEVV KEAVMDEVKK HFRPEFINRI DEIVVFNALD QKAIREIARI
     QIRKLAKRME QQNIGLDVTE AALDEIGKVG FDPLFGARPL RRAVQDYLEN QIAVDILKGK
     YAPGDTVFVD YVDGKFIFED RKDNR
//
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