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Database: UniProt
Entry: R6BRM4_9CLOT
LinkDB: R6BRM4_9CLOT
Original site: R6BRM4_9CLOT 
ID   R6BRM4_9CLOT            Unreviewed;       870 AA.
AC   R6BRM4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   RecName: Full=Chaperone protein ClpB {ECO:0000256|RuleBase:RU362034};
GN   Name=clpB {ECO:0000256|RuleBase:RU362034};
GN   ORFNames=BN513_00191 {ECO:0000313|EMBL:CDA61771.1};
OS   Clostridium sp. CAG:169.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262778 {ECO:0000313|EMBL:CDA61771.1, ECO:0000313|Proteomes:UP000018302};
RN   [1] {ECO:0000313|EMBL:CDA61771.1, ECO:0000313|Proteomes:UP000018302}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:169 {ECO:0000313|Proteomes:UP000018302};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE. {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|ARBA:ARBA00026057}.
CC   -!- SUBUNIT: Homohexamer; The oligomerization is ATP-dependent.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362034}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA61771.1}.
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DR   EMBL; CBCF010000135; CDA61771.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6BRM4; -.
DR   STRING; 1262778.BN513_00191; -.
DR   Proteomes; UP000018302; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009408; P:response to heat; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR017730; Chaperonin_ClpB.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03346; chaperone_ClpB; 1.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362034};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362034};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018302};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}; Stress response {ECO:0000256|RuleBase:RU362034}.
FT   DOMAIN          3..150
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   COILED          416..530
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
SQ   SEQUENCE   870 AA;  97805 MW;  7C479AD605196485 CRC64;
     MNAQKFTQKS LETIQLANNL ALENNNMQIE QEHLLYALLK IDQSLIAQLL KKMGKDPQAF
     MQAVKQEIDK MPGVTGSGRE AGKIYIAQDV DMVLAKAEKI ADSMKDEYVS VEHLMISLME
     NPNQHLKELF KLFDIQKNDF LQVLQQVRGN TRVTSDSPED TYDVLKKYGH DLVEDARNKK
     LDPVIGRDDE IRNVIMILSR KTKNNPVLIG EPGVGKTAIA EGLALRIVRG DVPASLKDKT
     IFSLDMGALI AGAKFRGEFE ERLKAVLSEI KKSEGKIILF IDELHTIVGA GKTEGSMDAG
     NLLKPMLARG ELHCIGATTL NEYRQYIEKD AALERRFQPV LVAEPSVEDT ISILRGLKER
     YEVYHGVKIQ DAALIAAATL SDRYISDRFL PDKAIDLVDE ACAMIRTEMD SMPIEMDELN
     RKIIQQEIAQ AALKKEEDKL SKERLEAVTK ELAQLREQFN SMKAQWDNEK TAISKVQKLR
     EEIEQTGGEI ERAEREYDLN KAAELKYGKL PQLKAELEKE EKLAEEAQQS SLLRDKVTEE
     EIAKVVGKWT GIPVAKIMEG EREKLLHMED ILHQNVVGQD EAVRLVSEAI LRSRAGISDP
     NRPIGSFLFL GPTGVGKTQL AKTLAKTLFD DENNMVRIDM SEYMEKYSVS RLIGAPPGYV
     GYEEGGQLTE AVRRRPYSVV LFDEVEKAHP DVFNVLLQVL DDGRITDSQG RTVDFKNTII
     ILTSNLGSSY ILEGITPDGE ISQQAKDEVN ALLKTNFRPE FLNRLDEIVF YKPLSRENIG
     SIIDLLMKDL QKRLEAKQIS LELTDRAKQL IIDEAYDPIY GARPLKRYLQ SHVETMLGRK
     IIAGEIGSAD QNGAGCRVQI DAENGELVVR
//
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