ID R6CU54_9CLOT Unreviewed; 1202 AA.
AC R6CU54;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN ORFNames=BN687_00838 {ECO:0000313|EMBL:CDA68857.1};
OS Clostridium sp. CAG:510.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262816 {ECO:0000313|EMBL:CDA68857.1, ECO:0000313|Proteomes:UP000018120};
RN [1] {ECO:0000313|EMBL:CDA68857.1, ECO:0000313|Proteomes:UP000018120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:510 {ECO:0000313|Proteomes:UP000018120};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA68857.1}.
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DR EMBL; CBCI010000077; CDA68857.1; -; Genomic_DNA.
DR AlphaFoldDB; R6CU54; -.
DR STRING; 1262816.BN687_00838; -.
DR Proteomes; UP000018120; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 1.
DR Gene3D; 1.10.287.1490; -; 2.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000018120}.
FT DOMAIN 537..654
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 197..224
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 264..340
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 369..403
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 439..515
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 695..792
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 849..953
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 48..55
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1202 AA; 136889 MW; 200BB239A26610FD CRC64;
MKRCLASENR AKEDRGMYLK SIEVYGFKSF ANKITFQFHN GITGIVGPNG SGKSNVADAV
RWVLGEQRIK QLRGSSMQDV IFSGTEARKP LSYAYVAITL DNSDHQLAID FDEVTVARRI
YRSGESEYLI NGAACRLKDV NELFYDTGIG KEGYSIIGQG QIDKILSGKP EERRELFDEA
AGIVKFKRRK FAAQKKLEDE KANLVRVNDI LSELEKQVKP LEKQSETAKI YLKKKEELKV
LDANTFLLES EQVKTQLADV QGKYDIASKD YEETSEKYEG IRQEYEAIQS RIETLEKEIE
EARNNLTDTS VLRGKLEGEI NVLKEQIHSA TDNAAHLQTR KVNLNSQIAQ KDTEKQEILA
KKAEIDEQVT ELTATRDEVK ISLESLQNRI QELNDSIEAG KNTIIDELNQ RATIKSKIGR
FDTMLEQVAI RKAELNSRIL KAKSDEEDRE ENIKKLKEQF TAVSDALKEM KEKAEKDEAD
IQKIRGELTG KDVKLRETQE QYHQEKSRLE ALSNLTERYE GYGGSVKKVM EQKNDNKGII
GVVADIIKVD KKYETAIETA LGGNIQNIVT DDEETAKKMI GFLKKNRLGR ATFLPLTSIK
NPQEFKNPEA LKEKGVVGMA DELVRTETRY KDVAKAMLGR IVVVDNVDNA VKIARKFDYG
IRMVTIEGEL LVPGGAISGG AFKNNSNLLG RRREMEDLEK KIKDLLSSIE TIQKDIEETK
QKRNTMRMEL EALKADIQRK FIEQNTARLS VESAEERMEE AEAGSRSLME ELKEMEKQVL
EIKQGKEEIQ KELTGSEEME KSVEAGISEF QKELEEKRLL ETESSAKVSE WELKVEKMLQ
TQGFHQQNVD RINAEIENLK GELSEIEDGI AGNEESLKEK KEHIAEIEKT IEASHTSQDK
SQKELTENIA KKEELSAKQK NFFTEREELS QQMTRLDKEV YRLNAQKEKM EEAMETQINY
MWDEYELTLS DAASLRKEEL TDLGSMKKEI SAIKDQIKKL GDVNVNAIED YKNLMERYTF
LKTQHDDLIE AEKTLEGIIT ELDSAMRKQF QEKFAEINKE FDKVFKELFG GGRGTLELME
DEDILEAGIR IIAQPPGKKL QNMMQLSGGE KALTAISLLF AIQNLKPSPF CLLDEIEAAL
DESNVGRFAK YLHKLTKNTQ FIVITHRRGT MEKADRLYGI TMQEKGVSAL VSVNLIDKDL
DN
//
