ID   R6D6T7_9FIRM            Unreviewed;       513 AA.
AC   R6D6T7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Band 7 domain-containing protein {ECO:0000259|SMART:SM00244};
GN   ORFNames=BN718_01812 {ECO:0000313|EMBL:CDA73567.1};
OS   Ruminococcus sp. CAG:579.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1262963 {ECO:0000313|EMBL:CDA73567.1, ECO:0000313|Proteomes:UP000018387};
RN   [1] {ECO:0000313|EMBL:CDA73567.1, ECO:0000313|Proteomes:UP000018387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:579 {ECO:0000313|Proteomes:UP000018387};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC       {ECO:0000256|ARBA:ARBA00007161}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA73567.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CBCK010000151; CDA73567.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6D6T7; -.
DR   STRING; 1262963.BN718_01812; -.
DR   Proteomes; UP000018387; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd03399; SPFH_flotillin; 1.
DR   Gene3D; 3.30.479.30; Band 7 domain; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR031905; Flotillin_C.
DR   InterPro; IPR027705; Flotillin_fam.
DR   PANTHER; PTHR13806:SF31; FLOTILLIN-LIKE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR13806; FLOTILLIN-RELATED; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   Pfam; PF15975; Flot; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018387};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          29..194
FT                   /note="Band 7"
FT                   /evidence="ECO:0000259|SMART:SM00244"
FT   REGION          478..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          206..259
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          295..399
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        487..507
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  56061 MW;  4E3B25A61A4D1A8D CRC64;
     MNFMEFVSSH IPQLGIAAGV VLLIIIIISG YCKAPPDEAY IISGLRKKVL IGKAGIKIPF
     LERLDKLSLK LISVDVKTAT SVPTADYINV RVDSVVNVKI SDQENKLALA AQNFLNQNSA
     YICSVAREVL EGNVREIVGQ MSLQDMVNDR KKFAEKVQDN AAPDLANMGL EIVSFNVQNL
     TDEQGLIENL GIDNTTKIQK TAAITKAEAE RDIQIAQARA SKESNDARVQ AETEIAQRNN
     ELAIRKAELK KQSDIKQAEA DAAYDIQQQE QRKTIEVTSS MADIAKTEQD VLLHAKQAEV
     QEQSLNAEVK KKADAERYRK EQEAQAALFQ RSKQAEAELY EQQKDAEAQK ARAEAMKYAK
     LQEAEGIRAV GEAEANAIRA KALAEAEGLN KKAEAMQKMQ EAAVLQMYFD VLPQVAKAVS
     EPLAKVGSIT MYGEGNSAKM IEDITRSTNQ VSSGMLEGIG IDLKSMINSF VTGRAIGQGI
     SANSDDTPKG DDTDHPAQPD NKEKPADNDT PQA
//