ID R6D9F1_9BACE Unreviewed; 1530 AA.
AC R6D9F1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Glutamine amidotransferase type-2 domain-containing protein {ECO:0000259|PROSITE:PS51278};
GN ORFNames=BN772_02807 {ECO:0000313|EMBL:CDA84375.1};
OS Bacteroides sp. CAG:754.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262750 {ECO:0000313|EMBL:CDA84375.1, ECO:0000313|Proteomes:UP000017906};
RN [1] {ECO:0000313|EMBL:CDA84375.1, ECO:0000313|Proteomes:UP000017906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:754 {ECO:0000313|Proteomes:UP000017906};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- COFACTOR:
CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC Evidence={ECO:0000256|ARBA:ARBA00001927};
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- SIMILARITY: Belongs to the glutamate synthase family.
CC {ECO:0000256|ARBA:ARBA00009716}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA84375.1}.
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DR EMBL; CBCP010000150; CDA84375.1; -; Genomic_DNA.
DR Proteomes; UP000017906; Unassembled WGS sequence.
DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0015930; F:glutamate synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00982; gltB_C; 1.
DR CDD; cd00713; GltS; 1.
DR CDD; cd02808; GltS_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 2.160.20.60; Glutamate synthase, alpha subunit, C-terminal domain; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR002489; Glu_synth_asu_C.
DR InterPro; IPR036485; Glu_synth_asu_C_sf.
DR InterPro; IPR006982; Glu_synth_centr_N.
DR InterPro; IPR002932; Glu_synthdom.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR PANTHER; PTHR11938; FAD NADPH DEHYDROGENASE/OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11938:SF133; GLUTAMATE SYNTHASE (NADH); 1.
DR Pfam; PF00310; GATase_2; 1.
DR Pfam; PF04898; Glu_syn_central; 1.
DR Pfam; PF01645; Glu_synthase; 1.
DR Pfam; PF01493; GXGXG; 1.
DR SUPFAM; SSF69336; Alpha subunit of glutamate synthase, C-terminal domain; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
PE 3: Inferred from homology;
KW 3Fe-4S {ECO:0000256|ARBA:ARBA00023291};
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000017906}.
FT DOMAIN 35..426
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
SQ SEQUENCE 1530 AA; 169244 MW; 00BBFDB9E9AAA4FD CRC64;
MKKQELFNNE TKGFPYQRQP RQAGLYDAAY EHDACGVGML VNIHGEKSHD VVESALKVLE
NMRHRGAEGA DNKTGDGAGI LLQIPHEFIL LQGIPVPEKG RYGTGLLFLP KNDKDQGAIL
SIIIEEIEKE GLTLMHLRNV PTCPEILGEA ALANEPDIKQ VFITGFTETE TADRKLYLIR
KRIENKVRLS SIPAKDDFYV VSLSTKSIIY KGMLSSLQLR NYYPDLTNSY FTSGLALVHS
RFSTNTFPTW GLAQPFRLLA HNGEINTIRG NRGWMEARES VLSSPTLGDI KEIRPIIQPG
MSDSASLDNV LEFLVMSGLS LPHAMAMLVP ESFNEKNPIS EELKAFYEYH SILMEPWDGP
AALLFSDGRF AGGMLDRNGL RPARYLITKN DMMVVASEVG VMDFEPGDIR EKGRLQPGKI
LLVDTEKGEI YYDGELKRQL AEAKPYRTWL STNRIELDEL KSGRKVPHHI ENYDRMLRTF
GYSKEDIERL IMPMASTGAE PIQSMGNDTP LAVLSDKPQL LYNYFRQQFA QVTNPPIDPL
REELVMSLTE YIGAVGMNIL TPSESHCKMV RLNHPILSNT QLDILCNIRY KGFKTVKLPM
LFEVEKGKAG LQEALGSLCK MAEESVTEGV NYIILSDRDV DAGHAVIPSL LAVSAVHHHL
ISVGKRVQTA LVVESGEIRE VMHAALLLGF GASALNPYMA FAVLDKLVKD RDIQLDYATA
EKNYMKSICK GLFKIMSKMG ISTIRSYRGA KIFEAVGLSE ELSKAYFGGL GSPIGGIRLE
EIARDAIAFH EEGFAKEVDG LLPNKGLYAF RKDGEKHAWN PETISTLQLA TRLGSYKKFK
EYTHLVDEKE KPIFLRDFLG FRRNPISIDR VEPVENILHR FVTGAMSFGS ISKEAHEAMA
IAMNKIHGRS NTGEGGEDAS RFQPLPDGSS LRSAIKQVAS GRFGVTAEYL VNADEIQIKI
AQGAKPGEGG QLPGFKVNDV IAKTRHSIPG ISLISPPPHH DIYSIEDLAQ LIFDLKNVNP
QAKISVKLVA ESGVGTIAAG VAKAKADLIV ISGAEGGTGA SPASSIRYAG ISPELGLSET
QQTLVLNGLR GQVVLQVDGQ LKTGRDIILM ALMGAEEYGF ATSALIVLGC VMMRKCHQNT
CPVGVATQDE ELRKRFHGRS EYLVNFFTFL AQEVREHLAE MGFTRMDDII GRTDLIERKS
VELKSVEHMS VEYKSEAHIP NPKHTLIDFT KMLARIDNSA AIRHVIDQDH GISTVKDVAI
IDAARDAIEH EKEISLEYTI ANTDRAIGAM LSGVIAKKQG ARGLPEHTLN VKFKGSAGQS
FGAFLVPGVN FKLEGEANDY LGKGLSGGRI AVLPPIRSNF EADKNTIAGN TLLYGATSGE
VYINGRVGER FAVRNSGAVA VVEGVGDHCC EYMTGGRVVV LGQTGRNFAA GMSGGVAYVW
NKDGNFDYFC NMEMVELSLI EEAGYRKELH ELIRQHYLYT GSKLARTMLD DWNHYVDQFI
QVVPIEYKKV LQEEQMRKLQ QKIADMQRDY
//
